Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/217928
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Non-proliferative neurogenesis in human periodontal ligament stem cells |
Autor: | Bueno, Carlos Roberto CSIC ORCID; Martinez-Morga, Marta; Martínez, Salvador CSIC ORCID | Fecha de publicación: | 2019 | Editor: | Springer Nature | Citación: | Scientific Reports 9: 18038 (2019) | Resumen: | Understanding the sequence of events from undifferentiated stem cells to neuron is not only important for the basic knowledge of stem cell biology, but also for therapeutic applications. In this study we examined the sequence of biological events during neural differentiation of human periodontal ligament stem cells (hPDLSCs). Here, we show that hPDLSCs-derived neural-like cells display a sequence of morphologic development highly similar to those reported before in primary neuronal cultures derived from rodent brains. We observed that cell proliferation is not present through neurogenesis from hPDLSCs. Futhermore, we may have discovered micronuclei movement and transient cell nuclei lobulation coincident to in vitro neurogenesis. Morphological analysis also reveals that neurogenic niches in the adult mouse brain contain cells with nuclear shapes highly similar to those observed during in vitro neurogenesis from hPDLSCs. Our results provide additional evidence that it is possible to differentiate hPDLSCs to neuron-like cells and suggest the possibility that the sequence of events from stem cell to neuron does not necessarily requires cell division from stem cell. | Versión del editor: | https://doi.org/10.1038/s41598-019-54745-3 | URI: | http://hdl.handle.net/10261/217928 | DOI: | 10.1038/s41598-019-54745-3 | E-ISSN: | 2045-2322 |
Aparece en las colecciones: | (IN) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
noneuroligam.pdf | 4,56 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
11
checked on 02-abr-2024
SCOPUSTM
Citations
13
checked on 03-may-2024
WEB OF SCIENCETM
Citations
11
checked on 26-feb-2024
Page view(s)
89
checked on 03-may-2024
Download(s)
77
checked on 03-may-2024