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Título: | Spread of Streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant clone, Spain |
Autor: | Ardanuy, Carmen; Campa, Adela G. de la CSIC ORCID; García, Ernesto CSIC ORCID ; Fenoll, Asunción; Calatayud, Laura; Cercenado, Emilia; Perez-Trallero, Emilio; Bouza, Emilio; Liñares, Josefina | Palabras clave: | Streptococcus pneumoniae Bacteria Antimicrobial resistance Fluoroquinolone resistance Sweden 15A-ST63 clone Serotype 8-ST63 Dissemination Spread Spain |
Fecha de publicación: | nov-2014 | Citación: | Emerg Infect Dis 20 (11) 1848-56 (2014) | Resumen: | Since 2004, a total of 131 isolates of Streptococcus pneumoniae multidrug-resistant invasive serotype 8 have been detected in Spain. These isolates showed resistance to erythromycin, clindamycin, tetracycline, and ciprofloxacin. All isolates were obtained from adult patients and shared a common genotype (sequence type [ST]63; penicillin-binding protein 1a [pbp1a], pbp2b, and pbp2x gene profiles; ermB and tetM genes; and a ParC-S79F change). Sixty-eight isolates that required a ciprofloxacin MIC ≥16 μg/mL had additional gyrA gene changes. Serotype 8-ST63 pbp2x sequences were identical with those of antimicrobial drug–susceptible serotype 8-ST53 isolates. Serotype 8-ST63 pbp2b sequences were identical with those of the multidrug-resistant Sweden 15A-ST63 clone. Recombination between the capsular locus and flanking regions of an ST53 isolate (donor) and an ST63 pneumococcus (recipient) generated the novel 15A-ST63 clone. One recombination point was upstream of pbp2x and another was within pbp1a. A serotype 8-ST63 clone was identified as a cause of invasive disease in Spain. | Descripción: | 9 p.-4 fig.-1 tab. | Versión del editor: | https://doi.org/10.3201/eid2011.131215 | URI: | http://hdl.handle.net/10261/214766 | DOI: | 10.3201/eid2011.131215 | ISSN: | 1080-6040 | E-ISSN: | 1080-6059 |
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