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http://hdl.handle.net/10261/212254
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dc.contributor.author | Merchante, Nicolás | es_ES |
dc.contributor.author | Figueruela, Blanca | es_ES |
dc.contributor.author | Rodríguez-Fernández, Miguel | es_ES |
dc.contributor.author | Rodríguez-Arrondo, Francisco | es_ES |
dc.contributor.author | Revollo, Boris | es_ES |
dc.contributor.author | Ibarra, Sofía | es_ES |
dc.contributor.author | Galindo, María José | es_ES |
dc.contributor.author | Merino, Esperanza | es_ES |
dc.contributor.author | Montero, Marta | es_ES |
dc.contributor.author | Téllez, Francisco | es_ES |
dc.contributor.author | García-Deltoro, Miguel | es_ES |
dc.contributor.author | Rivero-Juárez, Antonio | es_ES |
dc.contributor.author | Delgado-Fernández, Marcial | es_ES |
dc.contributor.author | Ríos-Villegas, María José | es_ES |
dc.contributor.author | Aguirrebengoa, Koldo | es_ES |
dc.contributor.author | García, María A. | es_ES |
dc.contributor.author | Portu, Joseba | es_ES |
dc.contributor.author | Vera-Méndez, Francisco Jesús | es_ES |
dc.contributor.author | Villalobos, Marina | es_ES |
dc.contributor.author | Mínguez, Carlos | es_ES |
dc.contributor.author | De Los Santos, Ignacio | es_ES |
dc.contributor.author | López-Ruz, Miguel A. | es_ES |
dc.contributor.author | Omar, Mohamed | es_ES |
dc.contributor.author | Galera-Peñaranda, Carlos | es_ES |
dc.contributor.author | Macías Sánchez, Juan | es_ES |
dc.contributor.author | Pineda, Juan A. | es_ES |
dc.date.accessioned | 2020-05-26T16:38:47Z | - |
dc.date.available | 2020-05-26T16:38:47Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | AIDS 33(2): 269-278 (2019) | es_ES |
dc.identifier.issn | 0269-9370 | - |
dc.identifier.uri | http://hdl.handle.net/10261/212254 | - |
dc.description | On behalf of the GEHEP-002 Study Group. | - |
dc.description.abstract | [Objective]: To assess the performance of ultrasound surveillance for the diagnosis of hepatocellular carcinoma (HCC) in HIV-infected patients. | es_ES |
dc.description.abstract | [Methods]: The GEHEP-002 cohort recruits HCC cases diagnosed in HIV-infected patients from 32 centers across Spain. The proportion of ‘ultrasound lack of detection’, defined as HCC diagnosed within the first 3 months after a normal surveillance ultrasound, and the proportion of ‘surveillance failure’, defined as cases in which surveillance failed to detect HCC at early stage, were assessed. To assess the impact of HIV, a control population of 104 HCC cases diagnosed in hepatitis C virus-monoinfected patients during the study period was used. | es_ES |
dc.description.abstract | [Results]: A total of 186 (54%) out of 346 HCC cases in HIV-infected patients were diagnosed within an ultrasound surveillance program. Ultrasound lack of detection occurred in 16 (8.6%) of them. Ultrasound surveillance failure occurred in 107 (57%) out of 186 cases diagnosed by screening, whereas this occurred in 18 (29%) out of 62 diagnosed in the control group (P < 0.0001). HCC cases after ultrasound surveillance failure showed a lower frequency of undetectable HIV viral load at diagnosis. The probability of 1-year and 2-year survival after HCC diagnosis among those diagnosed by screening was 56 and 45% in HIV-infected patients, whereas it was 79 and 64% in HIV-negative patients (P = 0.038). | es_ES |
dc.description.abstract | [Conclusion]: The performance of ultrasound surveillance of HCC in HIV-infected patients is very poor and worse than that shown outside HIV infection. A HCC surveillance policy based on ultrasound examinations every 6 months might be insufficient in HIV-infected patients with cirrhosis. | es_ES |
dc.description.sponsorship | The current study was supported by grants from the Consejería de Salud de la Junta de Andalucía (PI-0014/2014), the Servicio Andaluz de Salud (grant number SAS/111239) and the Fondo de Investigaciones Sanitarias ISCIII (grant number PI13/01621) and Project ‘PI16/01443’, funded by Instituto de Salud Carlos III, integrated in the national I+D+i 2013–2016 and co-funded by European Union (ERDF/ESF, ‘Investing in your future’). J.A.P. is the recipient of an intensification grant from the Instituto de Salud Carlos III (grant number Programa-I3SNS). Besides, this work has been partially funded by the Grupo para el Estudio de las Hepatitis Víricas (GEHEP) de la SEIMC (2017 grant to project GEHEP-002 and 2018 grant to project GEHEP-002), the SPANISH AIDS Research Network RD16/0025/0010 as part of the Plan Nacional R+D+I and cofinanced by ISCIII Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Lippincott Williams & Wilkins | es_ES |
dc.rights | closedAccess | es_ES |
dc.title | Low performance of ultrasound surveillance for the diagnosis of hepatocellular carcinoma in HIV-infected patients | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1097/QAD.0000000000002065 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1097/QAD.0000000000002065 | es_ES |
dc.identifier.e-issn | 1473-5571 | - |
dc.contributor.funder | Junta de Andalucía | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
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