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http://hdl.handle.net/10261/209383
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dc.contributor.author | Zhurinsky, Jacob | - |
dc.contributor.author | Salas-Pino, Silvia | - |
dc.contributor.author | Iglesias-Romero, Ana B. | - |
dc.contributor.author | Torres-Méndez, Antonio | - |
dc.contributor.author | Knapp, Benjamin | - |
dc.contributor.author | Flor-Parra, Ignacio | - |
dc.contributor.author | Wang, Jiyong | - |
dc.contributor.author | Bao, Kehan | - |
dc.contributor.author | Songtao, Jia | - |
dc.contributor.author | Chang, Fred | - |
dc.contributor.author | Daga, Rafael R. | - |
dc.date.accessioned | 2020-04-28T10:47:02Z | - |
dc.date.available | 2020-04-28T10:47:02Z | - |
dc.date.issued | 2019-10-01 | - |
dc.identifier.citation | Molecular Biology of the Cell 30(21): 2695-2708 (2019) | - |
dc.identifier.issn | 1059-1524 | - |
dc.identifier.uri | http://hdl.handle.net/10261/209383 | - |
dc.description.abstract | Although the function of microtubules (MTs) in chromosomal segregation during mitosis is well characterized, much less is known about the role of MTs in chromosomal functions during interphase. In the fission yeast Schizosaccharomyces pombe, dynamic cytoplasmic MT bundles move chromosomes in an oscillatory manner during interphase via linkages through the nuclear envelope (NE) at the spindle pole body (SPB) and other sites. Mto1 is a cytoplasmic factor that mediates the nucleation and attachment of cytoplasmic MTs to the nucleus. Here, we test the function of these cytoplasmic MTs and Mto1 on DNA repair and recombination during interphase. We find that mto1Δ cells exhibit defects in DNA repair and homologous recombination (HR) and abnormal DNA repair factory dynamics. In these cells, sister chromatids are not properly paired, and binding of Rad21 cohesin subunit along chromosomal arms is reduced. Our findings suggest a model in which cytoplasmic MTs and Mto1 facilitate efficient DNA repair and HR by promoting dynamic chromosomal organization and cohesion in the nucleus. | - |
dc.description.sponsorship | This work was supported by grants from the Spanish Ministry of Economy and Competitiveness BFU2011-15216-E, P09-CTS-4697, and PGC2018-099849-B-100 to R.R.D.; National Institutes of Health (NIH) R01, GM067690, and GM115185 to F.C.; and NIH grants R01-GM085145 and R35-GM126910 to S.J. | - |
dc.language | eng | - |
dc.publisher | American Society for Cell Biology | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-099849-B-100 | - |
dc.relation | PGC2018-099849-B-100/AEI/10.13039/501100011033 | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | Effects of the microtubule nucleator Mto1 on chromosomal movement, DNA repair, and sister chromatid cohesion in fission yeast. | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1091/mbc.E19-05-0301 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1091/mbc.E19-05-0301 | - |
dc.identifier.e-issn | 1939-4586 | - |
dc.date.updated | 2020-04-28T10:47:02Z | - |
dc.rights.license | https://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | - |
dc.contributor.funder | Agencia Estatal de Investigación (España) | - |
dc.contributor.funder | National Institutes of Health (US) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100000002 | es_ES |
dc.identifier.pmid | 31483748 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
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