Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/203763
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Redefining synchronous colorectal cancers based on tumor clonality |
Autor: | Perea, José; García, Juan L. CSIC ORCID CVN ; Corchete, Luis A.; Lumbreras, Eva CSIC ORCID; Arriba, María; Rueda, Daniel | Palabras clave: | Synchronous colorectal cancer Clonality Single‐Nucleotide Polymorphism array (SNP array) Colon location Monoclonal Polyclonal |
Fecha de publicación: | 1-abr-2019 | Editor: | John Wiley & Sons International Union against Cancer |
Citación: | International Journal of Cancer 144(7): 1596-1608 (2019) | Resumen: | To analyze the possible clonal origin of a part of Synchronous colorectal cancer (SCRC), we studied 104 paired‐SCRCs from 52 consecutive patients without hereditary forms of CRC. We used a Single‐Nucleotide Polymorphism array to characterize the genomic profiles, and subsequently used a statistical application to define them according to clonality within the same individual. We categorized the ensuing groups according to colonic location to identify differential phenotypes. The SCRC Monoclonal group (M) (19 cases) was divided into Monosegmental (MM) and Pancolonic (MP) groups. The SCRC Polyclonal group (P) (33 cases) was also divided into Monosegmental (PM) and Pancolonic (PP), the first exhibiting preference for left colon. The MM group showed a high rate of mucinous tumors, the lowest mean‐number of tumors and associated‐polyps, and the worst prognosis. The MP group included the largest mean‐number of associated‐polyps, best prognosis and familial cancer component. The PM group seemed to be a “frontier” group. Finally, the PP group also exhibited a mucin component, the highest mean‐number of tumors (4.6) compared with the mean‐number of polyps (7.7), poor prognosis and sporadic cases. Most relevant differential genomic regions within M groups were gains on 1q24 and 8q24, and deletions on 1p21 and 1p23 for MM, while within P were the gains on 7q36 and deletions on 1p36 for PM. The statistical application employed seems to define clonality more accurately in SCRC ‐more likely to be polyclonal in origin‐, and together with the tumor locations, helped us to configure a classification with prognostic and clinical value. | Versión del editor: | http://dx.doi.org/10.1002/ijc.31761 | URI: | http://hdl.handle.net/10261/203763 | DOI: | 10.1002/ijc.31761 | ISSN: | 0020-7136 | E-ISSN: | 1097-0215 |
Aparece en las colecciones: | (IBMCC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
8
checked on 08-may-2024
SCOPUSTM
Citations
8
checked on 06-may-2024
WEB OF SCIENCETM
Citations
8
checked on 22-feb-2024
Page view(s)
148
checked on 05-may-2024
Download(s)
25
checked on 05-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.