Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/201037
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Valero, Manuel | - |
dc.contributor.author | Averkin, Robert G. | - |
dc.contributor.author | Fernández-Lamo, Iván | - |
dc.contributor.author | Aguilar, Juan | - |
dc.contributor.author | López-Pigozzi, Diego | - |
dc.contributor.author | Brotons-Mas, Jorge R. | - |
dc.contributor.author | Cid Ledesma, Elena | - |
dc.contributor.author | Tamás, Gábor | - |
dc.contributor.author | Menéndez de la Prida, Liset | - |
dc.date.accessioned | 2020-02-18T09:48:43Z | - |
dc.date.available | 2020-02-18T09:48:43Z | - |
dc.date.issued | 2017-06-21 | - |
dc.identifier.citation | Neuron 94(6): 1234-1247 (2017) | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | http://hdl.handle.net/10261/201037 | - |
dc.description.abstract | Memory traces are reactivated selectively during sharp-wave ripples. The mechanisms of selective reactivation, and how degraded reactivation affects memory, are poorly understood. We evaluated hippocampal single-cell activity during physiological and pathological sharp-wave ripples using juxtacellular and intracellular recordings in normal and epileptic rats with different memory abilities. CA1 pyramidal cells participate selectively during physiological events but fired together during epileptic fast ripples. We found that firing selectivity was dominated by an event- and cell-specific synaptic drive, modulated in single cells by changes in the excitatory/inhibitory ratio measured intracellularly. This mechanism collapses during pathological fast ripples to exacerbate and randomize neuronal firing. Acute administration of a use- and cell-type-dependent sodium channel blocker reduced neuronal collapse and randomness and improved recall in epileptic rats. We propose that cell-specific synaptic inputs govern firing selectivity of CA1 pyramidal cells during sharp-wave ripples. | - |
dc.description.sponsorship | Supported by grants from the Spanish Ministerio de Economía y Competitividad (MINECO) to L.M.P. (BFU2012-37156-C03-01 and BFU2015-66887-R). M.V. was supported by a PhD fellowship from the Spanish Ministry of Education, Culture and Sports (FPU12/03776). R.G.A. and G.T. were supported by the ERC Interimpact project, the Hungarian Academy of Sciences, the Hungarian National Office for Research and Technology GINOP-2.3.2-15-2016-00018, and by the National Brain Research Program, Hungary. | - |
dc.language | eng | - |
dc.publisher | Elsevier | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2015-66887-R | - |
dc.rights | closedAccess | - |
dc.title | Mechanisms for Selective Single-Cell Reactivation during Offline Sharp-Wave Ripples and Their Distortion by Fast Ripples | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.neuron.2017.05.032 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.neuron.2017.05.032 | - |
dc.identifier.e-issn | 1097-4199 | - |
dc.date.updated | 2020-02-18T09:48:44Z | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Ministerio de Educación, Cultura y Deporte (España) | - |
dc.contributor.funder | Hungarian Academy of Sciences | - |
dc.contributor.funder | National Office for Research and Technology (Hungary) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003176 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
item.fulltext | No Fulltext | - |
Aparece en las colecciones: | (IC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
63
checked on 21-abr-2024
WEB OF SCIENCETM
Citations
61
checked on 24-feb-2024
Page view(s)
153
checked on 01-may-2024
Download(s)
14
checked on 01-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.