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dc.contributor.author | Fernández-Calvet, Ariadna | - |
dc.contributor.author | Euba, Begoña | - |
dc.contributor.author | Caballero, Lucía | - |
dc.contributor.author | Díez-Martínez, Roberto | - |
dc.contributor.author | Menéndez, Margarita | - |
dc.contributor.author | Ortiz-de-Solorzano, Carlos | - |
dc.contributor.author | Leiva, José | - |
dc.contributor.author | Micol, Vicente | - |
dc.contributor.author | Barrajón-Catalán, Enrique | - |
dc.contributor.author | Garmendia, Juncal | - |
dc.date.accessioned | 2019-12-20T14:10:35Z | - |
dc.date.available | 2019-12-20T14:10:35Z | - |
dc.date.issued | 2019-12-17 | - |
dc.identifier.citation | Biomolecules 9(12): 891 (2019) | - |
dc.identifier.issn | 2218-273X | - |
dc.identifier.uri | http://hdl.handle.net/10261/197150 | - |
dc.description.abstract | Chronic obstructive pulmonary disease (COPD) is characterized by abnormal inflammation and impaired airway immunity, providing an opportunistic platform for nontypeable <i>Haemophilus influenzae</i> (NTHi) infection. In this context, therapies targeting not only overactive inflammation without significant adverse effects, but also infection are of interest. Increasing evidence suggests that polyphenols, plant secondary metabolites with anti-inflammatory and antimicrobial properties, may be protective. Here, a <i>Cistus salviifolius</i> plant extract containing quercetin, myricetin, and punicalagin was shown to reduce NTHi viability. Analysis of these polyphenols revealed that quercetin has a bactericidal effect on NTHi, does not display synergies, and that bacteria do not seem to develop resistance. Moreover, quercetin lowered NTHi airway epithelial invasion through a mechanism likely involving inhibition of Akt phosphorylation, and reduced the expression of bacterially-induced proinflammatory markers <i>il-8</i>, <i>cxcl-1</i>, <i>il-6</i>, <i>pde4b</i>, and <i>tnfα</i>. We further tested quercetin’s effect on NTHi murine pulmonary infection, showing a moderate reduction in bacterial counts and significantly reduced expression of proinflammatory genes, compared to untreated mice. Quercetin administration during NTHi infection on a zebrafish septicemia infection model system showed a bacterial clearing effect without signs of host toxicity. In conclusion, this study highlights the therapeutic potential of the xenohormetic molecule quercetin against NTHi infection. | - |
dc.description.sponsorship | This work has been funded by grants from MINECO SAF2015-66520-R and RTI2018-096369-B-I00, PI011 from Economical Development Department, Regional Navarra Govern, Spain, and 31/2015 from SEPAR to J.G., by grant from MINECO DRTI2018-094494-B-C22 (MCIU/AEI/FEDER, UE) to C.O.S., by grants from MINECO AGL2015-67995-C3-1-R and RTI2018-096724-B-C21, PROMETEO/2016/006 from Generalitat Valenciana, and CIBERobn (CB12/03/30038) to V.M, by grant 03/2016 from Health Department, Regional Navarra Govern, Spain to J.G., C.O.S. and J.L, and by grant CIBERES (CB06/06/1102) to M.M. CIBER is an initiative from Instituto de Salud Carlos III (ISCIII), Madrid, Spain. | - |
dc.publisher | Multidisciplinary Digital Publishing Institute | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-66520-R | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-096369-B-I00 | - |
dc.relation | RTI2018-096369-B-I00/AEI/10.13039/501100011033 | - |
dc.relation | DRTI2018-094494-B-C22/AEI/10.13039/501100011033 | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/DRTI2018-094494-B-C22 | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | Preclinical Evaluation of the Antimicrobial-Immunomodulatory Dual Action of Xenohormetic Molecules against Haemophilus influenzae Respiratory Infection | - |
dc.identifier.doi | 10.3390/biom9120891 | - |
dc.relation.publisherversion | https://doi.org/10.3390/biom9120891 | - |
dc.identifier.e-issn | 2218-273X | - |
dc.date.updated | 2019-12-20T14:10:35Z | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | - |
dc.contributor.funder | Agencia Estatal de Investigación (España) | - |
dc.contributor.funder | Diputación Foral de Navarra | - |
dc.contributor.funder | Sociedad Española de Neumología y Cirugía Torácica | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Generalitat Valenciana | - |
dc.contributor.funder | Centro de Investigación Biomédica en Red Enfermedades Respiratorias (España) | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003359 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100007509 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.contributor.orcid | Fernández-Calvet, Ariadna [0000-0002-3340-703X] | - |
dc.contributor.orcid | Díez-Martínez, Roberto [0000-0001-8007-8163] | - |
dc.contributor.orcid | Menéndez, Margarita [0000-0002-3267-4443] | - |
dc.contributor.orcid | Ortiz de Solórzano, Carlos [0000-0001-8720-0205] | - |
dc.contributor.orcid | Micol, Vicente [0000-0001-8089-0696] | - |
dc.contributor.orcid | Barrajón-Catalán, Enrique [0000-0001-8113-0795] | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
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