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Título: | L-phenylalanine restores vascular function in spontaneously hypertensive rats through activation of the GCH1-GFRP complex |
Autor: | Heikal, Lamia; Starr, Anna; Hussein, Dania; Prieto-Lloret, Jesús CSIC ORCID; Aaronson, Philip I.; Dailey, Lea Ann; Nandi, Manasi | Palabras clave: | Cardiovascular diseases Endothelium l-phenylalanine Nitric oxide |
Fecha de publicación: | 2018 | Editor: | Elsevier | Citación: | JACC: Basic to Translational Science 3(3): 366-377 (2018) | Resumen: | Reduced nitric oxide (NO) bioavailability correlates with impaired cardiovascular function. NO is extremely labile and has been challenging to develop as a therapeutic agent. However, NO bioavailability could be enhanced by pharmacologically targeting endogenous NO regulatory pathways. Tetrahydrobiopterin, an essential cofactor for NO production, is synthesized by GTP cyclohydrolase-1 (GCH1), which complexes with GCH1 feedback regulatory protein (GFRP). The dietary amino acid l-phenylalanine activates this complex, elevating vascular BH4. Here, the authors demonstrate that l-phenylalanine administration restores vascular function in a rodent model of hypertension, suggesting the GCH1-GFRP complex represents a rational therapeutic target for diseases underpinned by endothelial dysfunction. | Versión del editor: | https://doi.org/10.1016/j.jacbts.2018.01.015 | URI: | http://hdl.handle.net/10261/196717 | DOI: | 10.1016/j.jacbts.2018.01.015 | E-ISSN: | 2452-302X |
Aparece en las colecciones: | (IBGM) Artículos |
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phenylcomple.pdf | 1,83 MB | Adobe PDF | Visualizar/Abrir |
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