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http://hdl.handle.net/10261/195696
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Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Martín-Blanco, Nadia M. | es_ES |
dc.contributor.author | Jiménez Teja, Daniel | es_ES |
dc.contributor.author | Bretones, Gabriel | es_ES |
dc.contributor.author | Borroto Revuelta, Aldo | es_ES |
dc.contributor.author | Caraballo, Michael | es_ES |
dc.contributor.author | Screpanti, I. | es_ES |
dc.contributor.author | Leon, Javier | es_ES |
dc.contributor.author | Alarcón, Balbino | es_ES |
dc.contributor.author | Cañelles, Matilde | es_ES |
dc.date.accessioned | 2019-11-27T10:07:16Z | - |
dc.date.available | 2019-11-27T10:07:16Z | - |
dc.date.issued | 2016-03 | - |
dc.identifier.citation | International Immunology | es_ES |
dc.identifier.issn | 0953-8178 | - |
dc.identifier.uri | http://hdl.handle.net/10261/195696 | - |
dc.description.abstract | Modulation of TCR signaling upon ligand binding is achieved by changes in the equilibrium between TCR degradation, recycling and synthesis; surprisingly, the molecular mechanism of such an important process is not fully understood. Here, we describe the role of a new player in the mediation of TCR degradation: the endocytic adaptor Numb. Our data show that Numb inhibition leads to abnormal intracellular distribution and defective TCR degradation in mature T lymphocytes. In addition, we find that Numb simultaneously binds to both Cbl and a site within CD3 epsilon that overlaps with the Nck binding site. As a result, Cbl couples specifically to the CD3 epsilon chain to mediate TCR degradation. The present study unveils a novel role of Numb that lies at the heart of TCR signaling initiation and termination. | es_ES |
dc.description.sponsorship | The work was funded by grants BFU2004-01771, BFU2007-67476 and BFU2010-21634 from the Spanish Science and Education Ministry, a Special Intramural CSIC (Spanish Science Council) grant and the Excellence grant P06-CTS-02112 from the Department of Science and Innovation of the Regional Government of Andalucia, Spain (M.C.), and grants SAF08-01581 and RD06/0020/0017 (J.L.). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Oxford University Press | es_ES |
dc.relation | BFU2004-01771 | es_ES |
dc.relation | BFU2007-67476 | es_ES |
dc.relation | BFU2010-21634 | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | lymphocyte signaling | es_ES |
dc.subject | T-cell activation | es_ES |
dc.subject | T-cell differentiation | es_ES |
dc.subject | T-cell receptor | es_ES |
dc.title | CD3 epsilon recruits Numb to promote TCR degradation | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1093/intimm/dxv060 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.identifier.e-issn | 1460-2377 | - |
dc.contributor.funder | Ministerio de Educación y Ciencia (España) | es_ES |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (España) | es_ES |
dc.contributor.funder | Junta de Andalucía | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003339 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.contributor.orcid | Leon, Javier [0000-0001-5803-0112] | es_ES |
dc.contributor.orcid | Alarcón, Balbino [0000-0001-7820-1070] | es_ES |
dc.identifier.pmid | 26507128 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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