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Title

Back cover: cytotoxic, antiangiogenic and antitelomerase activity of Glucosyl- and Acyl- resveratrol prodrugs and resveratrol sulfate metabolites (ChemBioChem 14/2016)

AuthorsFalomir, Eva; Lucas, Ricardo CSIC ORCID; Peñalver, Pablo CSIC ORCID; Martí-Centelles, Rosa; Dupont, Alexia; Zafra-Gómez, Alberto; Carda, Miguel; Morales, Juan C.
KeywordsProdrug
Resveratrol
Metabolite
Cytotoxicity
Antiproliferation
Angiogenesis
Issue Date18-Jul-2016
PublisherJohn Wiley & Sons
CitationChemBioChem 17(14): 1384-1384 (2016)
AbstractThe back cover picture shows how resveratrol (RES) prodrugs deliver resveratrol to the cell and how, later, RES gets metabolized mainly to RES sulfates in MCF‐7, HT‐29 and HEK‐293 cells. We found that RES glucosylated prodrugs were more cytotoxic in HT‐29 and MCF‐7 cells than RES itself. Likewise, some RES sulfates showed similar or higher cytotoxicity than RES. We also observed that VEGF production was decreased by RES glucosylated compounds, and RES‐disulfate diminished it even more than RES. More information about the resveratrol prodrugs as anticancer drugs and the biological activity of RES sulfates can be found in the full paper by M. Carda, J. C. Morales et al. on page 1343 in Issue 14, 2016 (DOI: 10.1002/cbic.201600084).
URIhttp://hdl.handle.net/10261/190286
DOIhttp://dx.doi.org/10.1002/cbic.201600356
ISSN1439-4227
E-ISSN1439-7633
Appears in Collections:(IIQ) Artículos
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