Novel Customizable sulfamate and sulfamidate units for antimicrobial Discovery

Abstract

Cyclic sulfamidates and sulfamides, that are available from 1,2-amino alcohols and 1,2-diols, are components of antimicrobial drugs, such as inhibitors of HIV-1 integrase and HIV protease, Hepatitis C NS5B polymerase, and bacterial AAK1 kinase. The ready and efficient transformation of monocyclic compounds (customizable units) into a diversity of derivatives (Scheme), according to the reaction conditions, is described herein. The versatility of this reaction allows the ready preparation of a library of potential new antimicrobial agents. The antimicrobial studies against several bacterial and viral strains is commented as well.