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dc.contributor.author | Almendros, Pedro | - |
dc.contributor.author | Yanai, H. | - |
dc.contributor.author | Hoshikawa, S. | - |
dc.contributor.author | Aragoncillo, Cristina | - |
dc.contributor.author | Lázaro-Milla, C. | - |
dc.contributor.author | Toledano-Pinedo, M. | - |
dc.contributor.author | Matsumoto, T. | - |
dc.contributor.author | Alcaide, Benito | - |
dc.date.accessioned | 2019-01-11T11:17:58Z | - |
dc.date.available | 2019-01-11T11:17:58Z | - |
dc.date.issued | 2018 | - |
dc.identifier | doi: 10.1039/c8qo00955d | - |
dc.identifier | issn: 2052-4110 | - |
dc.identifier | e-issn: 2052-4129 | - |
dc.identifier.citation | Organic Chemistry Frontiers 5: 3163-3169 (2018) | - |
dc.identifier.uri | http://hdl.handle.net/10261/173959 | - |
dc.description.abstract | Several heterocycles reacted with shelf-stable 2-(2-fluoropyridinium-1-yl)-1,1-bis[(trifluoromethyl)sulfonyl] ethan-1-ide, a latent TfCCH source, to give rise in a mild and controllable way to adducts via direct C-H bis[(trifluoromethyl)sulfonyl]ethylation reactions. This metal- and irradiation-free protocol is convenient. Besides, the volatile side-product 2-fluoropyridine can be smoothly eliminated under vacuum, which facilitates purification. The substrate scope survey discloses that exquisite chemo- and regioselectivities are achieved in a variety of heterocyclic systems. Of particular interest are the late-stage structural modification of known pharmaceuticals, such as the marketed drugs Phenazone (Antipyrine) and Edaravone, and the development of a water soluble fluorescent dye. | - |
dc.description.sponsorship | his work was supported by a Grant -in -Aid for Scientific Research on Innovative Areas ‘‘Advanced Molecular Transformations by Organocatalysts’’, a Grant-in -Aid for Scientific Research (C) (17K08224), Private University Research Branding Project, the Hoansha Foundation, and MINECO/FEDER (Projects CTQ2015-65060-C2-1-P and CTQ2015-65060-C2-2-P). C. L. -M. thanks MINECO for a predoctoral gran. | - |
dc.publisher | Royal Society of Chemistry (UK) | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2015-65060-C2-1-P | - |
dc.rights | closedAccess | - |
dc.title | Transition metal-free controlled synthesis of bis[(trifluoromethyl)sulfonyl]ethyl-decorated heterocycles | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1039/c8qo00955d | - |
dc.date.updated | 2019-01-11T11:17:59Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Ministerio de Economía, Industria y Competitividad (España) | - |
dc.contributor.funder | European Commission | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100010198 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
item.fulltext | No Fulltext | - |
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