Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/173417
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Combining Breath Figures and Supercritical Fluids to Obtain Porous Polymer Scaffolds |
Autor: | Castaño, Marta; Martínez-Campos, Enrique CSIC ORCID; Pintado-Sierra, Mercedes CSIC ORCID; García Sánchez, Carolina CSIC ORCID; Reinecke, Helmut CSIC ORCID; Gallardo Ruiz, Alberto CSIC ORCID; Rodríguez-Hernández, Juan CSIC ORCID; Elvira, Carlos CSIC ORCID | Fecha de publicación: | 2018 | Editor: | American Chemical Society | Citación: | ACS Omega 3: 12593-12599 (2018) | Resumen: | Supercritical fluids technology is a clean methodology to foam polymeric materials. However, this technique provides only the formation of inner porosity, whereas the so-called skin layer is commonly observed at the polymer surface. This article describes a new method for the preparation of outer and inner porous poly(ϵ-caprolactone) (PCL) scaffolds by combination of supercritical CO (SCCO) foaming and the breath figures technique. In the first step, experiments with a SCCO reactor were performed at 35-45 °C, 100-250 bar, and 1-20 min depressurization time. The effect of these parameters in the formation of inner porosity was investigated for an adequate optimization. In a late stage, to provide also surface porosity to the polymeric samples and remove the skin layer, the breath figures technique was employed. The evaluation of porosity was determined by scanning electronic microscopy, mercury porosimetry, and micro X-ray computerized tomography scanning processing the images obtained with the ImageJ software. The results of this study using these two complementary techniques showed the existence of interconnectivity between inner and outer porosity of the samples. Furthermore, thermal transitions and crystallinity of the PCL samples have been analyzed by differential scanning calorimetry. Finally, a preliminary biological evaluation of the resulting scaffolds with mouse endothelial cells (C166-GFP) was performed to assess their biocompatibility and cellular viability. | Versión del editor: | http://dx.doi.org/10.1021/acsomega.8b02024 | URI: | http://hdl.handle.net/10261/173417 | DOI: | 10.1021/acsomega.8b02024 | Identificadores: | doi: 10.1021/acsomega.8b02024 issn: 2470-1343 |
Aparece en las colecciones: | (IQOG) Artículos (ICTP) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
acsomega.8b02024.pdf | 13,46 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
4
checked on 18-mar-2024
SCOPUSTM
Citations
16
checked on 23-abr-2024
WEB OF SCIENCETM
Citations
12
checked on 25-feb-2024
Page view(s)
325
checked on 26-abr-2024
Download(s)
260
checked on 26-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.