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http://hdl.handle.net/10261/171463
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dc.contributor.author | Burlock, Brianna | - |
dc.contributor.author | Richardson, Gabrielle | - |
dc.contributor.author | García-Rodríguez, Sonia | - |
dc.contributor.author | Guerrero, Salvador | - |
dc.contributor.author | Zubiaur, Mercedes | - |
dc.contributor.author | Sancho, Jaime | - |
dc.date.accessioned | 2018-10-24T08:16:33Z | - |
dc.date.available | 2018-10-24T08:16:33Z | - |
dc.date.issued | 2018-09-25 | - |
dc.identifier.citation | International Journal of Molecular Sciences 19(10): 2906 (2018) | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/10261/171463 | - |
dc.description.abstract | Previous work from our group has shown that Cd38−/− mice develop a milder pristane-induced lupus disease than WT or Art2−/− counterparts, demonstrating a new role for CD38 in promoting aberrant inflammation and lupus-like autoimmunity via a Transient Receptor Potential Melastatin 2 (TRPM2)-dependent apoptosis-driven mechanism. In this study we asked whether CD38 may play a role in the expression and function of regulatory B cells (IL-10-producing B cells or B10 cells). In pristane-treated mice the frequency of spleen CD19+CD1dhiCD5+ B cells, which are highly enriched in B10 cells, was significantly increased in Cd38−/− splenocytes compared to WT, while the frequency of peritoneal plasmacytoid dendritic cells (pDCs), which are major type I Interferon (IFN) producers, was greatly diminished. The low proportion of pDCs correlated with lower amounts of IFN-α in the peritoneal lavage fluids of the Cd38−/− mice than of WT and Art2−/− mice. Functional ex vivo assays showed increased frequencies of IL-10-producing B cells in Cd38−/− splenocytes than in WT upon stimulation with an agonist anti-CD40 mAb. Overall these results strongly suggest that Cd38−/− mice are better suited than WT mice to generate and expand regulatory B10 cells following the appropriate stimulation. | - |
dc.description.sponsorship | Work performed in the Sancho and Zubiaur labs was supported in part by the European Commission in collaboration with the following Funding Agencies: (i) Junta de Andalucía, Consejería Innovación Ciencia y Empresa y Consejería Educación y Ciencia, Project: PC08-CTS-04046 to Jaime Sancho and Mercedes Zubiaur, and (ii) Ministerio de Economía y Competitividad (MINECO), Projects: SAF-2011-27261 and SAF-2017-89801-R to Jaime Sancho and Mercedes Zubiaur. The stay of B.B. and G.R. in Sancho’s lab was supported by National Science Foundation: Grant #HRD-0963629 (G-STEM). USA.; and U.S. Department of Education; Student Aid and Fiscal Responsibility Act; Title III Grant (SAFRA, Part F). Grant SAF-2017-89801-R covers in part the costs to publish in open access. | - |
dc.publisher | Multidisciplinary Digital Publishing Institute | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-89801-R | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | Bregs | - |
dc.subject | CD38 | - |
dc.subject | CD1dhi | - |
dc.subject | Lupus | - |
dc.subject | IL-10 | - |
dc.subject | Autoimmunity | - |
dc.subject | Inflammation | - |
dc.title | The Role of CD38 on the Function of Regulatory B Cells in a Murine Model of Lupus | - |
dc.type | artículo | - |
dc.identifier.doi | 10.3390/ijms19102906 | - |
dc.description.peerreviewed | Peer reviewed | - |
dc.relation.publisherversion | https://doi.org/10.3390/ijms19102906 | - |
dc.identifier.e-issn | 1422-0067 | - |
dc.date.updated | 2018-10-24T08:16:33Z | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Junta de Andalucía | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | National Science Foundation (US) | - |
dc.contributor.funder | Department of Education (US) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100000001 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100000138 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.identifier.pmid | 30257456 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
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ijms-19-02906.pdf | 2,3 MB | Adobe PDF | Visualizar/Abrir |
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