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http://hdl.handle.net/10261/165495
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Jimeno, Sonia | - |
dc.contributor.author | Herrera-Moyano, Emilia | - |
dc.contributor.author | Ortega, Pedro | - |
dc.contributor.author | Aguilera, Andrés | - |
dc.date.accessioned | 2018-06-01T09:02:48Z | - |
dc.date.available | 2018-06-01T09:02:48Z | - |
dc.date.issued | 2017 | - |
dc.identifier | doi: 10.1016/j.dnarep.2017.06.030 | - |
dc.identifier | e-issn: 1568-7856 | - |
dc.identifier | issn: 1568-7864 | - |
dc.identifier.citation | DNA Repair 57: 66-75 (2017) | - |
dc.identifier.uri | http://hdl.handle.net/10261/165495 | - |
dc.description.abstract | Eukaryotic cells possess several DNA endonucleases that are necessary to complete different steps in DNA metabolism. Rad2/XPG and Rad27/FEN1 belong to a group of evolutionary conserved proteins that constitute the Rad2 family. Given the important roles carried out by these nucleases in DNA repair and their capacity to create DNA breaks, we have investigated the effect that in vivo imbalance of these nucleases and others of the family have on genome integrity and cell proliferation. We show that overexpression of these nucleases causes genetic instability in both yeast and human cells. Interestingly, the type of recombination event and DNA damage induced suggest specific modes and timing of action of each nuclease that are beyond their known DNA repair function and are critical to preserve genome integrity. In addition to identifying new sources of genome instability, a hallmark of cancer cells, this study provides new genetic tools for studies of genome dynamics. | - |
dc.description.sponsorship | This study was supported by grants from the Spanish Ministry of Economy and Competitiveness (BFU2013-42918-PGN1 and BFU2016-75058P), the Junta de Andalucía (BIO-1238) and the European Union(FEDER). P.O. was the recipient of a FPU predoctoral training grant from the Spanish Ministry of Education, Culture and Sports. CABIMER is a Center partially funded by the Junta de Andalucía. | - |
dc.publisher | Elsevier | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2016-75058-P | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2013-42918-P | - |
dc.rights | closedAccess | - |
dc.subject | Rad27/FEN1 | - |
dc.subject | Rad2/XPG family | - |
dc.subject | Homologous recombination | - |
dc.subject | Genetic instability | - |
dc.title | Differential effect of the overexpression of Rad2/XPG family endonucleases on genome integrity in yeast and human cells | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.dnarep.2017.06.030 | - |
dc.date.updated | 2018-06-01T09:02:48Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Junta de Andalucía | - |
dc.contributor.funder | Ministerio de Educación, Cultura y Deporte (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003176 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.identifier.pmid | 28704715 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
item.fulltext | No Fulltext | - |
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