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Título: | GABA modulation of cholinergic transmission in rat oviduct |
Autor: | Fernández I; Orensanz, L.; Ceballos, María L. de CSIC ORCID | Fecha de publicación: | 1984 | Editor: | Elsevier | Citación: | Life Sciences 35: 357- 364 (1984) | Resumen: | The effects of electrical stimulation, gamma-aminobutyric acid (GABA), acetylcholine (ACh), norepinephrine (NE), 5-hydroxytryptamine (5-HT), GABA agonists and bicuculline were studied on spontaneous movements of isolated rat oviduct. The tissue did not respond to electrical stimulation or to GABA, NE and 5-HT when added to the incubation medium. ACh produced contractions related to its concentration which were maximal at the diestrous-1 phase when GABA caused a 20% rise in the ACh contraction. This effect was mimicked by GABA agonists whereas it was suppressed by bicuculline. beta-Estradiol benzoate (EB) increased ACh contractions in diestrous-1 and in the late proestrous phases. GABA did not modify the EB effect. Progesterone did not modify ACh contractions in any of the studied phases. These findings suggest a possible modulatory role for GABA on ACh responses in the isolated rat oviduct | URI: | http://hdl.handle.net/10261/155114 | Identificadores: | issn: 0024-3205 |
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