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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/150609
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dc.contributor.authorDillon, M. B. C.es_ES
dc.contributor.authorBellés, Xavieres_ES
dc.contributor.authorPiulachs, Maria-Dolorses_ES
dc.contributor.authorSette, Alessandroes_ES
dc.date.accessioned2017-05-30T07:12:04Z-
dc.date.available2017-05-30T07:12:04Z-
dc.date.issued2015-12-
dc.identifier.citationClinical and Experimental Allergy 45(12): 1856-1867 (2015)es_ES
dc.identifier.issn0954-7894-
dc.identifier.urihttp://hdl.handle.net/10261/150609-
dc.descriptionDillon, M. B. C. et al.es_ES
dc.description.abstract[Background and objective] The allergenicity of several German cockroach (Bla-g) antigens at the level of IgE responses is well established. However, less is known about the specificity of CD4+ TH responses, and whether differences exist in associated magnitude or cytokine profiles as a function of disease severity.es_ES
dc.description.abstract[Methods] Proteomic and transcriptomic techniques were used to identify novel antigens recognized by allergen-specific T cells. To characterize different TH functionalities of allergen-specific T cells, ELISPOT assays with sets of overlapping peptides covering the sequences of known allergens and novel antigens were employed to measure release of IL-5, IFNγ, IL-10, IL-17 and IL-21.es_ES
dc.description.abstract[Results] Using these techniques, we characterized TH responses in a cohort of adult Bla-g-sensitized subjects, either with (n = 55) or without (n = 17) asthma, and nonsensitized controls (n = 20). T cell responses were detected for ten known Bla-g allergens and an additional ten novel Bla-g antigens, representing in total a 5-fold increase in the number of antigens demonstrated to be targeted by allergen-specific T cells. Responses of sensitized individuals regardless of asthma status were predominantly TH2, but higher in patients with diagnosed asthma. In asthmatic subjects, Bla-g 5, 9 and 11 were immunodominant, while, in contrast, nonasthmatic-sensitized subjects responded mostly to Bla-g 5 and 4 and the novel antigen NBGA5.es_ES
dc.description.abstract[Conclusions] Asthmatic and nonasthmatic cockroach-sensitized individuals exhibit similar TH2-polarized responses. Compared with nonasthmatics, however, asthmatic individuals have responses of higher magnitude and different allergen specificity.es_ES
dc.description.sponsorshipThis project has been funded in whole or in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under contract numbers HHSN272200900052C and HHSN272201000052I and grant numbers 1UM1AI114271-01 and U19AI100275.es_ES
dc.language.isoenges_ES
dc.publisherWiley-Blackwelles_ES
dc.rightsclosedAccesses_ES
dc.subjectAsthmaes_ES
dc.subjectCD4(+) T-cellses_ES
dc.subjectCockroach allergyes_ES
dc.subjectEpitopees_ES
dc.titleDifferent Bla-g T cell antigens dominate responses in asthma versus rhinitis subjectses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1111/cea.12643-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1111/cea.12643es_ES
dc.identifier.e-issn1365-2222-
dc.contributor.funderNational Institutes of Health (US)es_ES
dc.relation.csicSíes_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/100000002es_ES
dc.identifier.pmid26414909-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeartículo-
item.fulltextNo Fulltext-
item.languageiso639-1en-
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