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Título: | Genetic structure of the abd-A gene of Drosophila |
Autor: | Busturia, Ana CSIC; Casanova, Jordi CSIC ORCID ; Sánchez-Herrero, Ernesto CSIC ORCID ; González, Rosa; Morata, Ginés CSIC ORCID | Palabras clave: | Drosophila Bithorax complex Homeotic genes |
Fecha de publicación: | 1989 | Editor: | Company of Biologists | Citación: | Development 107: 575- 583 (1989) | Resumen: | We report the embryonic and adult phenotypes of a number of mutations of the abd-A gene of the bithorax complex. Some of them result in loss of abd-A function in the whole abd-A domain and are usually lethal. These probably eliminate or inactivate abd-A protein products. Other mutations affect only part of the abd-A domain. These are viable, appear to map outside the abd-A transcription unit, and presumably alter the normal spatial regulation of abd-A products. We propose a model of abd-A structure based on a protein-coding region and two cis-regulatory regions. Regulatory region 1, 3' to the transcription unit, contains positive and negative regulatory elements. Regulatory region 2, 5' to the transcription unit, establishes the correct level of abd-A activity in the abdominal metameres | URI: | http://hdl.handle.net/10261/150086 | Identificadores: | issn: 0950-1991 |
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MorataG_GeneticStructure.pdf | 3,52 MB | Adobe PDF | Visualizar/Abrir |
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