Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/116731
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Planas, Anna M. | - |
dc.contributor.author | Solé, Sònia | - |
dc.contributor.author | Justicia, Carles | - |
dc.date.accessioned | 2015-06-17T11:39:15Z | - |
dc.date.available | 2015-06-17T11:39:15Z | - |
dc.date.issued | 2001 | - |
dc.identifier | doi: 10.1006/nbdi.2001.0435 | - |
dc.identifier | issn: 0969-9961 | - |
dc.identifier.citation | Neurobiology of Disease 8(5): 834-846 (2001) | - |
dc.identifier.uri | http://hdl.handle.net/10261/116731 | - |
dc.description.abstract | Matrix metalloproteinases (MMPs) degrade the extracellular matrix and carry out key functions during development and after injury. By means of zymography, Western blot and immunohistochemistry, we studied MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in rat brain after focal cerebral ischemia. The control rat brain showed constitutive MMP-2 and, to a lesser extent, MMP-9, which were mainly present as prozymogens. MMP-2 protein was located in the cell body of neurons, glia, and endothelium, whereas MMP-9 was associated to neurons and myelinated fibre tracts. Ischemia greatly increased MMP activation in two temporal waves, in the first one, MMP-9 protein was induced from 4 h to 4 days, and also a small and short-lasting increase in MMP-2 was detected at 4 h. The second wave showed a massive increase in MMP-2 protein expression and activation by day 4, which was compatible with abundant MMP-2 in reactive microglia/macrophages. Our results are compatible with progressive induction of MMP-9 proform, likely in neurons, shortly after ischemia. For MMP-2, the results suggest a discrete production immediately after reperfusion, while a very enhanced expression and activation of MMP-2 attributable to microglia/macrophages occurs on day 4, and it might contribute to the phagocytic action of these reactive cells. © 2001 Academic Press. | - |
dc.description.sponsorship | This study was supported by FIS Grant 00/0957. C. Justicia and S. Solé had fellowships from IDIBAPS | - |
dc.publisher | Academic Press | - |
dc.rights | closedAccess | - |
dc.subject | MMP-2 | - |
dc.subject | Gelatinase | - |
dc.subject | Extracellular matrix | - |
dc.subject | Middle cerebral artery | - |
dc.subject | MMP-9 | - |
dc.title | Expression and activation of matrix metalloproteinase-2 and -9 in rat brain after transient focal cerebral ischemia | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1006/nbdi.2001.0435 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1006/nbdi.2001.0435 | - |
dc.date.updated | 2015-06-17T11:39:15Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
item.fulltext | No Fulltext | - |
Aparece en las colecciones: | (IIBB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
234
checked on 24-abr-2024
WEB OF SCIENCETM
Citations
209
checked on 24-feb-2024
Page view(s)
265
checked on 25-abr-2024
Download(s)
130
checked on 25-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.