Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/114042
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Hepatic preconditioning in rats is defined by a balance of adenosine and xanthine |
Autor: | Peralta, Carmen; Closa, Daniel CSIC ORCID; Xaus, Carme CSIC; Gelpí, Emili CSIC; Roselló-Catafau, Joan CSIC ORCID; Hotter, Georgina CSIC ORCID | Fecha de publicación: | 1998 | Editor: | John Wiley & Sons | Citación: | Hepatology 28(3): 768-773 (1998) | Resumen: | The present work investigates the relationship between adenosine, nitric oxide (NO), and free radicals during ischemic preconditioning in rat liver. For this purpose, we evaluated: 1) the efficacy of different periods of preconditioning; 2) the changes in the concentration of adenine nucleotides during preconditioning; 3) the importance of adenosine and xanthine concentrations in the induction of preconditioning; and 4) the possible effect of xanthine oxidase-derived superoxide anion on NO during preconditioning. Results show that just a 10- to 15-minute period of ischemia followed by 10-minute reperfusion prevents the ischemic damage that would be induced by a subsequent 90 minutes of ischemia followed by 90 minutes of reperfusion. Administration of xanthine or metabolization of endogenous adenosine abolishes the protective effect of preconditioning. When rats have been subjected to a period of preconditioning not within the effective time window (10-15 minutes), and thus offering no protection, the administration of a NO donor was found to restore the protection. The dose needed to restore protection appears to be proportional to the endogenous xanthine concentration. In addition, when xanthine oxidase was inhibited, preconditioning effectively offered protection in front of ischemia and reperfusion, independently of the xanthine concentration. Altogether, this indicates that the time window of ischemia capable to induce preconditioning in liver is defined by the relative tissue concentrations of adenosine and xanthine. The lower limit of this window (10 minutes) is defined by the amount of adenosine able to induce NO generation. Its upper limit (15 minutes) is defined by the concentration of xanthine able to remove the generated NO. | Versión del editor: | http://dx.doi.org/10.1002/hep.510280325 | URI: | http://hdl.handle.net/10261/114042 | DOI: | 10.1002/hep.510280325 | Identificadores: | doi: 10.1002/hep.510280325 issn: 0270-9139 |
Aparece en las colecciones: | (IIBB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
108
checked on 22-abr-2024
WEB OF SCIENCETM
Citations
95
checked on 25-feb-2024
Page view(s)
316
checked on 23-abr-2024
Download(s)
103
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.