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Insights into the origin of metazoan filopodia and microvilli

AuthorsSebé-Pedrós, Arnau ; Burkhardt, Pawel; Sánchez-Pons, Núria ; Fairclough, Stephen R.; Lang, B. Franz; King, Nicole; Ruiz-Trillo, Iñaki
Gelsolin evolution
Formin evolution
Issue DateJun-2013
PublisherOxford University Press
CitationMolecular Biology and Evolution 30(9): 2013-2023 (2013)
AbstractFilopodia are fine actin-based cellular projections used for both environmental sensing and cell motility, and they are essential organelles for metazoan cells. In this study, we reconstruct the origin of metazoan filopodia and microvilli. We first report on the evolutionary assembly of the filopodial molecular toolkit and show that homologs of many metazoan filopodial components, including fascin and myosin X, were already present in the unicellular or colonial progenitors of metazoans. Furthermore, we find that the actin crosslinking protein fascin localizes to filopodia-like structures and microvilli in the choanoflagellate Salpingoeca rosetta. In addition, homologs of filopodial genes in the holozoan Capsaspora owczarzaki are upregulated in filopodia-bearing cells relative to those that lack them. Therefore, our findings suggest that proteins essential for metazoan filopodia and microvilli are functionally conserved in unicellular and colonial holozoans and that the last common ancestor of metazoans bore a complex and specific filopodial machinery. © 2013 The Author.
DescriptionThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Publisher version (URL)http://dx.doi.org/10.1093/molbev/mst110
Identifiersdoi: 10.1093/molbev/mst110
issn: 0737-4038
e-issn: 1537-1719
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