Derechos | Preview | Fecha Public. | Título | Autor(es) | Tipo |
closedAccess | | 2017 | A natural product inhibits the initiation of α-synuclein aggregation & suppresses its toxicity | Perni, M.; Galvagnion, C.; Maltsev, A.; Meisl, G.; Müller, M.B.D.; Challa, P.K.; Kirkegaard, J.B.; Flagmeier, P.; Cohen, S.I.A.; Cascella, R.; Chen, S.W.; Limbocker, Ryan; Sormanni, P.; Heller, G.T.; Aprile, F.A.; Cremades, Nunilo; Cecchi, C.; Chiti, Fabrizio; Nollen, E.A.A.; Knowles, T.P.J.; Vendruscolo, M.; Bax, A.; Zasloff, M.; Dobson, C.M. | artículo |
closedAccess | | 30-ago-2021 | All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of α-synuclein toxic species | Franco, Aitor CSIC; Gracia, Pablo; Colom, Adai CSIC ORCID; Camino, José D.; Fernández-Higuero, José Ángel CSIC ORCID; Orozco, Natalia; Dulebo, Alexander; Dulebo, Alexander; Saiz, Leonor; Cremades, Nunilo; Vilar, Jose M. G. CSIC ORCID; Prado, Adelina CSIC ORCID; Muga, Arturo CSIC ORCID | artículo |
closedAccess | | 30-ago-2021 | All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of α-synuclein toxic species | Franco, Aitor CSIC; Gracia, Pablo; Colom, Adai CSIC ORCID; Camino, José D.; Fernández-Higuero, José Ángel CSIC ORCID; Orozco, Natalia; Dulebo, Alexander; Saiz, Leonor; Cremades, Nunilo; Vilar, Jose M. G. CSIC ORCID; Prado, Adelina CSIC ORCID; Muga, Arturo CSIC ORCID | artículo |
closedAccess | | 30-ago-2021 | All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of α-synuclein toxic species | Franco, Aitor CSIC; Gracia, Pablo; Colom, Adai CSIC ORCID; Camino, José D.; Fernández-Higuero, José Ángel CSIC ORCID; Orozco, Natalia; Dulebo, Alexander; Dulebo, Alexander; Saiz, Leonor; Cremades, Nunilo; Vilar, Jose M. G. CSIC ORCID; Prado, Adelina CSIC ORCID; Muga, Arturo CSIC ORCID | artículo |
openAccess | | 30-mar-2016 | Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing | Pedersen, Jeppe T.; Chen, Serene W.; Borg, Christian B.; Ness, Samuel; Bahl, Justyna M.; Heegaard, Niels H. H.; Dobson, Christopher M.; Hemmingsen, Lars; Cremades, Nunilo; Teilum, Kaare | artículo |
closedAccess | | 2-sep-2009 | Discovery of specific flavodoxin inhibitors as potential therapeutic agents against Helicobacter pylori infection | Cremades, Nunilo; Velázquez-Campoy, Adrián; Martínez-Júlvez, Marta; Neira, José L. CSIC ORCID; Pérez-Dorado, Inmaculada CSIC ORCID; Hermoso, Juan A. CSIC ORCID; Jiménez Sierra, M. Pilar CSIC ; Lanas, Ángel; Hoffman, Paul S.; Sancho, Javier CSIC ORCID | artículo |
openAccess | | 28-jun-2013 | Hsp70 Oligomerization Is Mediated by an Interaction between the Interdomain Linker and the Substrate-Binding Domain | Aprile, Francesco A.; Dhulesia, Anne; Stengel, Florian; Roodveldt, Cintia CSIC ORCID; Benesch, Justin L.P.; Tortora, Paolo; Robinson, Carol V.; Salvatella, Xavier; Dobson, Christopher M.; Cremades, Nunilo | artículo |
closedAccess | | 2017 | Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species | Aprile, F.A.; Arosio, P.; Fusco, Giuliana; Chen, S.W.; Kumita, J.R.; Dhulesia, Anne; Tortora, P.; Knowles, T.P.J.; Vendruscolo, M.; Dobson, C.M.; Cremades, Nunilo | artículo |
openAccess | | 6-ago-2022 | Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau | Gracia, Pablo; Polanco, David; Tarancón-Díez, Jorge; Serra, Ilenia; Bracci, Maruan; Oroz, Javier CSIC ORCID; Laurents, Douglas V. CSIC ORCID ; García, Inés; Cremades, Nunilo | artículo |
openAccess | | 28-oct-2020 | Multiplicity of α-synuclein aggregated species and their possible roles in disease | Gracia, Pablo; Camino, José D.; Volpicelli-Daley, Laura; Cremades, Nunilo | artículo |
openAccess | | 28-jun-2018 | Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine | Perni, Michele; Flagmeier, P.; Limbocker, Ryan; Cascella, R.; Aprile, Francesco A.; Galvagnion, C.; Heller, G.T.; Meisl, G.; Chen, S.W.; Kumita, J.R.; Challa, P.K.; Kirkegaard, J.B.; Cohen, S.I.A.; Mannini, Benedetta; Barbut, Denise; Nollen, E.A.A.; Cecchi, C.; Cremades, Nunilo; Knowles, Tuomas P. J.; Chiti, Fabrizio; Zasloff, Michael; Vendruscolo, Michele; Dobson, Christopher M. | artículo |
openAccess | | 15-dic-2017 | Structural basis of membrane disruption and cellular toxicity by a-synuclein oligomers | Fusco, Giuliana; Chen, Serene W.; Williamson, Philip T. F.; Cascella, Roberta; Perni, Michele; Jarvis, James A.; Cecchi, Cristina; Vendruscolo, Michele; Chiti, Fabrizio; Cremades, Nunilo; Ying, Liming; Dobson, Christopher M.; De Simone, Alfonso | artículo |
closedAccess | | 2018 | The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases | Cremades, Nunilo; Dobson, C.M. | artículo |
openAccess | | 15-oct-2020 | The extent of protein hydration dictates the preference for heterogeneous or homogeneous nucleation generating either parallel or antiparallel β-sheet α-synuclein aggregates | Camino, José D.; Gracia, Pablo; Chen, S.W.; Sot, Jesús CSIC ORCID; Arada, Igor de la CSIC ORCID; Sebastián, Víctor CSIC ORCID; Arrondo, José Luis R.; Goñi, Félix M. CSIC ORCID; Dobson, Christopher M.; Cremades, Nunilo | artículo |
openAccess | | 22-mar-2021 | The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells | Cascella, Roberta; Chen, Serene W.; Bigi, A.; Camino, José D.; Xu, C.K.; Dobson, Christopher M.; Chiti, Fabrizio; Cremades, Nunilo; Cecchi, Cristina | artículo |
openAccess | | 22-mar-2021 | The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells | Cascella, Roberta; Chen, Serene W.; Bigi, A.; Camino, José D.; Xu, C.K.; Dobson, Christopher M.; Chiti, Fabrizio; Cremades, Nunilo; Cecchi, Cristina | artículo |
openAccess | | 22-mar-2021 | The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells | Cascella, Roberta; Chen, Serene W.; Bigi, A.; Camino, José D.; Xu, C.K.; Dobson, Christopher M.; Chiti, Fabrizio; Cremades, Nunilo; Cecchi, Cristina | artículo |
openAccess | | feb-2021 | The role of water in the primary nucleation of protein amyloid aggregation | Camino, José D.; Gracia, Pablo; Cremades, Nunilo | artículo |
openAccess | | 13-ago-2020 | Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism | Limbocker, Ryan; Mannini, Benedetta; Ruggeri, F.S.; Cascella, R.; Xu, C.K.; Perni, M.; Chia, S.; Chen, S.W.; Habchi, J.; Bigi, A.; Kreiser, R.P.; Wright, A.K.; Albright, J.A.; Kartanas, T.; Kumita, J.R.; Cremades, Nunilo; Zasloff, M.; Cecchi, C.; Knowles, T.P.J.; Chiti, Fabrizio; Vendruscolo, M.; Dobson, Christopher M. | artículo |
openAccess | | 18-jun-2021 | α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity | Santos, Jaime; Gracia, Pablo; Navarro, Susanna; Peña-Díaz, Samuel; Pujols, Jordi; Cremades, Nunilo; Pallarés, Irantzu; Ventura, Salvador | artículo |