Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/99424
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | UCP2 deficiency helps to restrict the pathogenesis of experimental cutaneous and visceral leishmaniosis in mice |
Autor: | Carrión, Javier CSIC ORCID; Abengozar, M. A. CSIC; Fernández-Reyes, María CSIC ORCID; Sánchez-Martín, Carlos CSIC ORCID; Rial, Eduardo CSIC ORCID ; Domínguez-Bernal, Gustavo; González-Barroso, M. Mar | Fecha de publicación: | 1-feb-2013 | Editor: | Public Library of Science | Citación: | PLoS Negl Trop Dis(2013) 7(2): e2077 | Resumen: | BACKGROUND: Uncoupling protein 2 (UCP2) is a mitochondrial transporter that has been shown to lower the production of reactive oxygen species (ROS). Intracellular pathogens such as Leishmania upregulate UCP2 and thereby suppress ROS production in infected host tissues, allowing the multiplication of parasites within murine phagocytes. This makes host UCP2 and ROS production potential targets in the development of antileishmanial therapies. Here we explore how UCP2 affects the outcome of cutaneous leishmaniosis (CL) and visceral leishmaniosis (VL) in wild-type (WT) C57BL/6 mice and in C57BL/6 mice lacking the UCP2 gene (UCP2KO). METHODOLOGY AND FINDINGS: To investigate the effects of host UCP2 deficiency on Leishmania infection, we evaluated parasite loads and cytokine production in target organs. Parasite loads were significantly lower in infected UCP2KO mice than in infected WT mice. We also found that UCP2KO mice produced significantly more interferon-¿ (IFN-¿), IL-17 and IL-13 than WT mice (P<0.05), suggesting that UCP2KO mice are resistant to Leishmania infection. CONCLUSIONS: In this way, UCP2KO mice were better able than their WT counterparts to overcome L. major and L. infantum infections. These findings suggest that upregulating host ROS levels, perhaps by inhibiting UPC2, may be an effective approach to preventing leishmaniosis. | Descripción: | 10 p.-4 fig.3 tab. | Versión del editor: | http://dx.doi.org/10.1371/journal.pntd.0002077 | URI: | http://hdl.handle.net/10261/99424 | DOI: | 10.1371/journal.pntd.0002077 | ISSN: | 1935-2727 | E-ISSN: | 1935-2735 |
Aparece en las colecciones: | (CIB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Plos-Neglected Tropical Diseases-2013, Carrión.pdf | 780,16 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
9
checked on 16-mar-2024
SCOPUSTM
Citations
15
checked on 18-abr-2024
WEB OF SCIENCETM
Citations
13
checked on 25-feb-2024
Page view(s)
337
checked on 26-abr-2024
Download(s)
234
checked on 26-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.