Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/89336
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Differential responses to anxiogenic drugs in a mouse model of panic disorder as revealed by Fos immunocytochemistry in specific areas of the fear circuitry |
Autor: | Murtra, Patricia CSIC; Trullas, Ramón CSIC ORCID; Maldonado, Rafael; Estivill, Xavier CSIC; Dierssen, Mara CSIC | Palabras clave: | Amygdala Fos immunohistochemistry Panic disorder Locus ceruleus TrkC NT-3 Caffeine Yohimbine |
Fecha de publicación: | 2007 | Editor: | Springer Nature | Citación: | Amino Acids 33(4): 677-688 (2007) | Resumen: | Sensitivity to pharmacological challenges has been reported in patients with panic disorder. We have previously validated transgenic mice overexpressing the neurotrophin-3 (NT-3) receptor, TrkC (TgNTRK3), as an engineered murine model of panic disorder. We could determine that TgNTRK3 mice presented increased cellularity in brain regions, such as the locus ceruleus, that are important neural substrates for the expression of anxiety in severe anxiety states. Here, we investigated the sensitivity to induce anxiety and panic-related symptoms by sodium lactate and the effects of various drugs (the α2-adrenoceptor antagonist, yohimbine and the adenosine antagonist, caffeine), in TgNTRK3 mice. We found enhanced panicogenic sensitivity to sodium lactate and an increased intensity and a differential pattern of Fos expression after the administration of yohimbine or caffeine in TgNTRK3. Our findings validate the relevance of the NT-3/TrkC system to pathological anxiety and raise the possibility that a specific set of fear-related pathways involved in the processing of anxiety-related information may be differentially activated in panic disorder. © 2006 Springer-Verlag. | URI: | http://hdl.handle.net/10261/89336 | DOI: | 10.1007/s00726-006-0464-1 | Identificadores: | doi: 10.1007/s00726-006-0464-1 issn: 0939-4451 e-issn: 1438-2199 |
Aparece en las colecciones: | (IIBB) Artículos (IN) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
12
checked on 06-may-2024
WEB OF SCIENCETM
Citations
10
checked on 19-feb-2024
Page view(s)
369
checked on 08-may-2024
Download(s)
125
checked on 08-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.