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http://hdl.handle.net/10261/81483
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Pérez-Victoria, J. M. | - |
dc.contributor.author | Tincusi, B. M. | - |
dc.contributor.author | Jiménez, I. A. | - |
dc.contributor.author | Bazzocchi, I. L. | - |
dc.contributor.author | Gupta, M. P. | - |
dc.contributor.author | Castanys, Santiago | - |
dc.contributor.author | Gamarro, Francisco | - |
dc.contributor.author | Ravelo, Ángel G. | - |
dc.date.accessioned | 2013-09-05T09:29:01Z | - |
dc.date.available | 2013-09-05T09:29:01Z | - |
dc.date.issued | 1999 | - |
dc.identifier | doi: 10.1021/jm991066b | - |
dc.identifier | issn: 0022-2623 | - |
dc.identifier.citation | Journal of Medicinal Chemistry 42: 4388- 4393 (1999) | - |
dc.identifier.uri | http://hdl.handle.net/10261/81483 | - |
dc.description.abstract | The effects produced by nine dihydro-β-agarofuran sesquiterpenes isolated from Crossopetalum tonduzii (1-8) and Maytenus macrocarpa (9) (Celastraceae) on the reversion of the resistant phenotype on a multidrug- resistant Leishmania line and their binding to recombinant C-terminal nucleotide-binding domain of Leishmania P-glycoprotein-like transporter were studied. The structures of the new compounds (1-5) were elucidated by spectroscopic methods, including 1H-13C heteronuclear correlation (HMQC), long-range correlation spectra with inversal detection (HMBC), ROESY experiments; and chemical correlations. The absolute configuration of one of them (1) was determined by CD studies. The structure-activity relationship is discussed. | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.rights | closedAccess | - |
dc.title | New natural sesquiterpenes as modulators of daunomycin resistance in a multidrug-resistant Leishmania tropica line | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1021/jm991066b | - |
dc.date.updated | 2013-09-05T09:29:02Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
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