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http://hdl.handle.net/10261/80092
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | García-Silva, Susana | - |
dc.contributor.author | Pérez-Juste, Germán | - |
dc.contributor.author | Aranda, Ana | - |
dc.date.accessioned | 2013-07-23T11:21:06Z | - |
dc.date.available | 2013-07-23T11:21:06Z | - |
dc.date.issued | 2002 | - |
dc.identifier | doi: 10.1016/S0300-483X(02)00277-9 | - |
dc.identifier | issn: 0300-483X | - |
dc.identifier | e-issn: 1879-3185 | - |
dc.identifier.citation | Toxicology 181-182: 179-182 (2002) | - |
dc.identifier.uri | http://hdl.handle.net/10261/80092 | - |
dc.description.abstract | The thyroid hormone (T3) blocks proliferation and induces differentiation of neuroblastoma N2a-β cells that overexpress the β1 isoform of the T3 receptor. An element in the region responsible for premature termination of transcription mediates a rapid repression of c-myc gene expression by T3. The hormone also causes a decrease of cyclin D1 gene transcription, and is able to antagonize the activation of the cyclin D1 promoter by Ras. In addition, a strong and sustained increase of the levels of the cyclin kinase inhibitor (CKI) p27Kip1 are found in T3-treated cells. The increased levels of p27Kip1 lead to a marked inhibition of the kinase activity of the cyclin-CDK2 complexes. As a consequence of these changes, retinoblastoma proteins are hypophosphorylated in T3-treated N2a-β cells, and progression through the restriction point in the cell cycle is blocked. © 2002 Elsevier Science Ireland Ltd. All rights reserved. | - |
dc.description.sponsorship | This research was supported by Grant PM97-0135 from the DGES. | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.rights | closedAccess | - |
dc.title | Cell cycle control by the thyroid hormone in neuroblastoma cells | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/S0300-483X(02)00277-9 | - |
dc.date.updated | 2013-07-23T11:21:06Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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