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http://hdl.handle.net/10261/77203
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Pereira, Fábio | - |
dc.contributor.author | Larriba, María Jesús | - |
dc.contributor.author | Muñoz Terol, Alberto | - |
dc.date.accessioned | 2013-05-30T11:24:52Z | - |
dc.date.available | 2013-05-30T11:24:52Z | - |
dc.date.issued | 2012 | - |
dc.identifier | doi: 10.1530/ERC-11-0388 | - |
dc.identifier | issn: 1351-0088 | - |
dc.identifier | e-issn: 1479-6821 | - |
dc.identifier.citation | Endocrine-Related Cancer 19(3): R51-R71 (2012) | - |
dc.identifier.uri | http://hdl.handle.net/10261/77203 | - |
dc.description.abstract | The most active vitamin D metabolite, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), is a pleiotropic hormone with wide regulatory actions. Classically, vitamin D deficiency was known to alter calcium and phosphate metabolism and bone biology. In addition, recent epidemiological and experimental studies support the association of vitamin D deficiency with a large variety of human diseases, and particularly with the high risk of colorectal cancer. By regulating the expression of many genes via several mechanisms, 1,25(OH)2D3 induces differentiation, controls the detoxification metabolism and cell phenotype, sensitises cells to apoptosis and inhibits the proliferation of cultured human colon carcinoma cells. Consistently, 1,25(OH)2D3 and several of its analogues decrease intestinal tumourigenesis in animal models. Molecular, genetic and clinical data in humans are scarce but they suggest that vitamin D is protective against colon cancer. Clearly, the available evidence warrants new, well-designed, large-scale trials to clarify the role of vitamin D in the prevention and/or therapy of this important neoplasia. | - |
dc.description.sponsorship | The work in the authors’ laboratory is supported by Ministerio de Ciencia e Innovación of Spain (grant number SAF2010-18302), Fondo Europeo de Desarrollo Regional- Instituto de Salud Carlos III (grant number RD06/0020/0009) and Comunidad de Madrid (grant number S2011/BMD-2344, Colomics2). | - |
dc.language.iso | eng | - |
dc.publisher | Society for Endocrinology | - |
dc.relation | S2011/BMD-2344/COLOMICS2 | - |
dc.relation.isversionof | Postprint | - |
dc.rights | openAccess | - |
dc.title | Vitamin D and colon cancer | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1530/ERC-11-0388 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1530/ERC-11-0388 | - |
dc.date.updated | 2013-05-30T11:24:53Z | - |
dc.description.version | Peer Reviewed | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.contributor.funder | Comunidad de Madrid | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | European Commission | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100012818 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | artículo | - |
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Vitamin D and colon cancer.pdf | 339,09 kB | Adobe PDF | Visualizar/Abrir |
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