Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/59405
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Enhanced CREB-dependent gene expression increases the excitability of neurons in the basal amygdala and primes the consolidation of contextual and cued fear memory |
Autor: | Viosca, José CSIC; López de Armentia, Mikel CSIC; Jancic, Dragana CSIC; Barco, Ángel CSIC ORCID | Fecha de publicación: | 2009 | Editor: | Cold Spring Harbor Laboratory Press | Citación: | Learning and Memory 16(3): 193- 197 (2009) | Resumen: | Regulated expression of a constitutively active form of cAMP response element-binding protein (CREB), VP16-CREB, lowers the threshold for the late phase of long-term potentiation in the Schaffer collateral pathway in a de novo gene expression-independent manner, and increases the excitability and reduces afterhyperpolarization of neurons at the amygdala and the hippocampus. We explore the consequences of these changes on the consolidation of fear conditioning and find that the expression of VP16-CREB can bypass the requirement for de novo gene expression associated with long- term memory formation, suggesting that CREB-dependent gene expression is sufficient for fear memory consolidation. © 2009 Cold Spring Harbor Laboratory Press. | URI: | http://hdl.handle.net/10261/59405 | DOI: | 10.1101/lm.1254209 | Identificadores: | doi: 10.1101/lm.1254209 issn: 1072-0502 e-issn: 1549-5485 |
Aparece en las colecciones: | (IN) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
89
checked on 19-abr-2024
WEB OF SCIENCETM
Citations
77
checked on 21-feb-2024
Page view(s)
326
checked on 26-abr-2024
Download(s)
99
checked on 26-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.