Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/47606
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Phenocopies of Bithorax mutants |
Autor: | Capdevila, M. P.; García-Bellido, Antonio CSIC | Palabras clave: | Drosophila Melanogaster Bithorax Homoeotic mutants Clonal analysis Determination Gene regulation Phenocopies |
Fecha de publicación: | 1978 | Editor: | Springer Nature | Citación: | Wilhelm Roux's Archives of Developmental Biology 185 (2): 105-126 (1978) | Resumen: | Exposure to ether of wild-type embryos of different strains ofDrosophila melanogaster causes phenocopies of different alleles of thebithorax system. Clonal analysis of the phenocopy spots has shown that the transformation caused by the treatment is maintained by cell heredity. Embryos heterozygous for several recessive mutant alleles ofbithorax show the same frequency of phenocopies as wild-type homozygous sib controls. The same holds for embryos heterozygous for the dominant mutant allelesCbx andUbx 1 which are point mutants in thecis-regulatory region of the system. However, for dominant mutants which have breakpoints in this region (Ubx 80,Ubx 130 andHm) the frequency of phenocopies is about twice that of their sib controls. Embryos with increasing numbers of copies (from 1 to 4) of thebithorax system show a decreasing frequency of phenocopies. A model is proposed that explains ldquobithoraxrdquo phenocopies as resulting from disturbances in the distribution of positional information signals for segments (inductor molecules) which compete with the product of a regulator gene (repressor) and thecis-regulatory region of thebithorax system. On this model, the initiation of a metathoracic developmental pathway would result from the derepression of thebithorax system. | Versión del editor: | http://dx.doi.org/10.1007/BF00848672 | URI: | http://hdl.handle.net/10261/47606 | DOI: | 10.1007/BF00848672 | ISSN: | 0340-0794 |
Aparece en las colecciones: | (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Embargo.pdf | 21,67 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
25
checked on 09-abr-2024
WEB OF SCIENCETM
Citations
41
checked on 27-feb-2024
Page view(s)
314
checked on 05-may-2024
Download(s)
195
checked on 05-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.