Please use this identifier to cite or link to this item:
http://hdl.handle.net/10261/41225
Share/Export:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Title: | Molecular Bases of Caloric Restriction Regulation of Neuronal Synaptic Plasticity |
Authors: | Fontán-Lozano, Ángela CSIC ORCID; López-Lluch, Guillermo CSIC ORCID CVN ; Delgado-García, José María CSIC; Navas, Plácido CSIC ORCID; Carrión Rodríguez, Ángel Manuel CSIC ORCID | Keywords: | Caloric restriction Intermittent fasting diet Learning Consolidation Hippocampus Perirhinal cortex Mitochondria NMDA receptors Long-term potentiation Aging Neurodegenerative diseases Pain Analgesia |
Issue Date: | 30-Aug-2008 | Publisher: | Humana Press | Citation: | Molecular Neurobiology 38(2): 167-177 (2008) | Abstract: | Aging is associated with the decline of cognitive properties. This situation is magnified when neurodegenerative processes associated with aging appear in human patients. Neuronal synaptic plasticity events underlie cognitive properties in the central nervous system. Caloric restriction (CR; either a decrease in food intake or an intermittent fasting diet) can extend life span and increase disease resistance. Recent studies have shown that CR can have profound effects on brain function and vulnerability to injury and disease. Moreover, CR can stimulate the production of new neurons from stem cells (neurogenesis) and can enhance synaptic plasticity, which modulate pain sensation, enhance cognitive function, and may increase the ability of the brain to resist aging. The beneficial effects of CR appear to be the result of a cellular stress response stimulating the production of proteins that enhance neuronal plasticity and resistance to oxidative and metabolic insults; they include neurotrophic factors, neurotransmitter receptors, protein chaperones, and mitochondrial biosynthesis regulators. In this review, we will present and discuss the effect of CR in synaptic processes underlying analgesia and cognitive improvement in healthy, sick, and aging animals. We will also discuss the possible role of mitochondrial biogenesis induced by CR in regulation of neuronal synaptic plasticity. | Description: | 11 páginas. | Publisher version (URL): | http://dx.doi.org/10.1007/s12035-008-8040-1 | URI: | http://hdl.handle.net/10261/41225 | DOI: | 10.1007/s12035-008-8040-1 | ISSN: | 0893-7648 | E-ISSN: | 1559-1182 |
Appears in Collections: | (CABD) Artículos |
Show full item record
CORE Recommender
SCOPUSTM
Citations
78
checked on Apr 29, 2024
WEB OF SCIENCETM
Citations
74
checked on Feb 27, 2024
Page view(s)
351
checked on May 4, 2024
Google ScholarTM
Check
Altmetric
Altmetric
WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.