Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/4047
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Drosophila mus301/spindle-C Encodes a Helicase With an Essential Role in Double-Strand DNA Break Repair and Meiotic Progression |
Autor: | McCaffrey, Ruth; St Johnston, Daniel; González-Reyes, Acaimo CSIC ORCID | Palabras clave: | mus301 Drosophila Chromosome segregation Meiosis DNA breaks Recombination Oogenesis |
Fecha de publicación: | nov-2006 | Editor: | Genetics Society of America | Citación: | Genetics 174(3): 1273–1285 (2006) http://dx.doi.org/10.1534/genetics.106.058289 |
Resumen: | mus301 was identified independently in two genetic screens, one for mutants hypersensitive to chemical mutagens and another for maternal mutants with eggshell defects. mus301 is required for the proper specification of the oocyte and for progression through meiosis in the Drosophila ovary. We have cloned mus301 and show that it is a member of the Mus308 subfamily of ATP-dependent helicases and the closest homolog of human and mouse HEL308. Functional analyses demonstrate that Mus301 is involved in chromosome segregation in meiosis and in the repair of double-strand-DNA breaks in both meiotic and mitotic cells. Most of the oogenesis defects of mus301 mutants are suppressed by mutants in the checkpoint kinase Mei41 and in MeiW68, the Spo11 homolog that is thought to generate the dsDNA breaks that initiate recombination, indicating that these phenotypes are caused by activation of the DNA damage checkpoint in response to unrepaired Mei-W68-induced dsDNA breaks. However, neither mei-W68 nor mei-41 rescue the defects in oocyte specification of mus301 mutants, suggesting that this helicase has another function in oocyte selection that is independent from its role in meiotic recombination. | URI: | http://hdl.handle.net/10261/4047 | DOI: | 10.1534/genetics.106.058289 | ISSN: | 0016-6731 |
Aparece en las colecciones: | (CABD) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
McCaffrey_genetics.pdf | 2,62 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
22
checked on 01-may-2024
SCOPUSTM
Citations
42
checked on 02-may-2024
WEB OF SCIENCETM
Citations
39
checked on 25-feb-2024
Page view(s)
402
checked on 07-may-2024
Download(s)
272
checked on 07-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.