Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/37761
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Spo0A, the key transcriptional regulator for entrance into sporulation, is an inhibitor of DNA replication |
Autor: | Castilla, Virginia; Muñoz-Espín, D.; Villar, Laurentino CSIC; Salas, Margarita CSIC ORCID ; Meijer, Wilfried J. J. CSIC ORCID | Palabras clave: | B. subtilis Spo0A |
Fecha de publicación: | 3-ago-2006 | Editor: | Nature Publishing Group | Citación: | Embo Journal 25: 3890 - 3899 (2006) | Resumen: | The transcription factor Spo0A is a master regulator for entry into sporulation in Bacillus subtilis and also regulates expression of the virulent B. subtilis phage 29. Here, we describe a novel function for Spo0A, being an inhibitor of DNA replication of both, the 29 genome and the B. subtilis chromosome. Binding of Spo0A near the 29 DNA ends, constituting the two origins of replication of the linear 29 genome, prevents formation of 29 protein p6-nucleoprotein initiation complex resulting in inhibition of 29 DNA replication. At the B. subtilis oriC, binding of Spo0A to specific sequences, which mostly coincide with DnaA-binding sites, prevents open complex formation. Thus, by binding to the origins of replication, Spo0A prevents the initiation step of DNA replication of either genome. The implications of this novel role of Spo0A for phage 29 development and the bacterial chromosome replication during the onset of sporulation are discussed. | Versión del editor: | http://dx.doi.org/10.1038/sj.emboj.7601266 | URI: | http://hdl.handle.net/10261/37761 | DOI: | 10.1038/sj.emboj.7601266 | ISSN: | 0261-4189 |
Aparece en las colecciones: | (CBM) Artículos |
Mostrar el registro completo
CORE Recommender
PubMed Central
Citations
28
checked on 07-may-2024
SCOPUSTM
Citations
46
checked on 09-may-2024
WEB OF SCIENCETM
Citations
48
checked on 22-feb-2024
Page view(s)
316
checked on 10-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.