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dc.contributor.author | Montero-Atalaya, Marta | - |
dc.contributor.author | Muñoz-Arnaiz, Ricardo | - |
dc.contributor.author | Makarova, Julia | - |
dc.contributor.author | Bartolomé, Begoña | - |
dc.contributor.author | Moreno-Arribas, M. Victoria | - |
dc.contributor.author | Herreras, Óscar | - |
dc.date.accessioned | 2024-04-15T10:36:43Z | - |
dc.date.available | 2024-04-15T10:36:43Z | - |
dc.date.issued | 2023 | - |
dc.identifier | doi: 10.1016/j.ibneur.2023.08.590 | - |
dc.identifier | issn: 2667-2421 | - |
dc.identifier.citation | IBRO Neuroscience Reports 15: S321- S322 (2023) | - |
dc.identifier.uri | http://hdl.handle.net/10261/353828 | - |
dc.description.abstract | Dietary polyphenols have beneficial effects in situations of impaired cognition in acute models of neurodegeneration. Reported changes in blood flow might explain these effects. However, the possibility that they may have a direct effect on the electrical activity of neuronal populations has not been tested. Given the slow temporal dynamics of the cognitive and pathological events in which polyphenols have been implicated, it would be particularly relevant to explore any sustained and long-term changes to electrical activity. We explored in anesthetized female rats the systemic and direct effects of protochatechuic acid (PCA) on the CA1 population excitability. Also, we searched for sustained changes of ongoing network activity using state-of-the-art analytical techniques for brain source separation (independent component analysis) that provided pathway-specific field potential (FP) generators from laminar FPs simultaneously recorded in cortex and hippocampus using high density linear arrays across the CA1 and DG fields. | - |
dc.description.sponsorship | This work was supported by the Spanish Ministerio de Ciencia e Innovación (OH, PID2019-111587RB-I00, EM, PID2020-116327GB100; MVMA and BB, PID2019-108851RB-C21; and MM, PRE2020093312) and by the Agencia Estatal de Evaluación, Next Generation EU grant (PDC2021-121103-I00) to OH. | - |
dc.language | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-111587RB-I00/ES/CATALOGO DE GENERADORES DE POTENCIALES DE CAMPO EN CEREBRO COMPLETO SANO Y DURANTE PATOLOGIA CEREBRAL/ | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-108851RB-C21/ES/RELACION ENTRE EL CONSUMO DE VINO, LA DIETA Y LA MODULACION DEL MICROBIOMA EN LA ENFERMEDAD DE ALZHEIMER EN UNA COHORTE DE MADRID (ESPAÑA)/ | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | evoked potentials | - |
dc.subject | field potential generators | - |
dc.subject | hippocampus | - |
dc.subject | polyphenols | - |
dc.subject | protochatechuic acid (PCA). | - |
dc.title | Dietary polyphenol metabolite alters ca1 excitability and disengages corticohippocampal activities in anesthetized animals | - |
dc.type | artículo | - |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.ibneur.2023.08.590 | - |
dc.date.updated | 2024-04-15T10:36:44Z | - |
dc.rights.license | https://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.contributor.funder | Agencia Estatal de Investigación (España) | - |
dc.contributor.funder | European Commission | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairetype | artículo | - |
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