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http://hdl.handle.net/10261/352914
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Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Magnus Thorén | es_ES |
dc.contributor.author | Escudero-Martínez, Irene | es_ES |
dc.contributor.author | Andersson, Tomas | es_ES |
dc.contributor.author | Chen, Shih-Yin | es_ES |
dc.contributor.author | Tsao, Nicole | es_ES |
dc.contributor.author | Khurana, Dheeraj | es_ES |
dc.contributor.author | Beretta, Simone | es_ES |
dc.contributor.author | Peeters, Andre | es_ES |
dc.contributor.author | Tsivgoulis, Georgios | es_ES |
dc.contributor.author | Roffe, Christine | es_ES |
dc.contributor.author | Ahmed, Niaz | es_ES |
dc.date.accessioned | 2024-04-04T12:51:31Z | - |
dc.date.available | 2024-04-04T12:51:31Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.citation | International Journal of Stroke 18(10): 1193-1201 (2023) | es_ES |
dc.identifier.issn | 1747-4930 | - |
dc.identifier.uri | http://hdl.handle.net/10261/352914 | - |
dc.description | © 2023 World Stroke Organization, Article Reuse Guidelines. | es_ES |
dc.description.abstract | Background: A large infarct and expanding cerebral edema (CED) due to a middle cerebral artery occlusion confers a 70% mortality unless treated surgically. There is still conflicting evidence whether reperfusion is associated with a lower risk for CED in acute ischemic stroke. Aim: To investigate the association of reperfusion with development of early CED after stroke thrombectomy. Methods: From the SITS-International Stroke Thrombectomy Registry, we selected patients with occlusion of the intracranial internal carotid or middle cerebral artery (M1 or M2). Successful reperfusion was defined as mTICI ⩾ 2b. Primary outcome was moderate or severe CED, defined as focal brain swelling ⩾1/3 of the hemisphere on imaging scans at 24 h. We used regression methods while adjusting for baseline variables. Effect modification by severe early neurological deficits, as indicators of large infarct at baseline and at 24 h, were explored. Results: In total, 4640 patients, median age 70 years and median National Institutes of Health Stroke Score (NIHSS) 16, were included. Of these, 86% had successful reperfusion. Moderate or severe CED was less frequent among patients who had reperfusion compared to patients without reperfusion: 12.5% versus 29.6%, p < 0.05, crude risk ratio (RR) 0.42 (95% confidence interval (CI): 0.37–0.49), and adjusted RR 0.50 (95% CI: 0.44-0.57). Analysis of effect modification indicated that severe neurological deficits weakened the association between reperfusion and lower risk of CED. The RR reduction was less favorable in patients with severe neurological deficits, defined as NIHSS score 15 or more at baseline and at 24 h, used as an indicator for larger infarction. Conclusion: In patients with large artery anterior circulation occlusion stroke who underwent thrombectomy, successful reperfusion was associated with approximately 50% lower risk for early CED. Severe neurological deficit at baseline seems to be a predictor for moderate or severe CED also in patients with successful reperfusion by thrombectomy. | es_ES |
dc.description.sponsorship | SITS is financed directly and indirectly by grants from Karolinska Institutet, Stockholm County Council, and the Swedish Heart-Lung Foundation as well as from an unrestricted sponsorship from Boehringer Ingelheim. SITS has previously received grants from the European Union Framework 7, the European Union Public Health Authority and Ferrer International and EVER Pharma. SITS is currently conducting studies supported by Boehringer Ingelheim. SITS has previously conducted study supported by Stryker, Covidien and Phenox in collaboration with Karolinska Institutet. M.T. has received grants or funding from Stiftelsen Tornspiran, Stiftelsen Sigurd och Elsa Goljes Minne, STROKE-Riksförbundet, Capio forskningsstiftelse, and Karolinska University Hospital. I.E-M. has received a grant from “Fundación Progreso y Salud, Junta de Andalucía” (grant EF-0437-2018). N.A. received grants from Stockholm County Council and the Swedish Heart-Lung Foundation. | es_ES |
dc.format | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Sage Publications | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.relation.isbasedon | Magnus Thorén; Escudero-Martínez, Irene; Andersson, Tomas; Chen, Shih-Yin; Tsao, Nicole; Khurana, Dheeraj; Beretta, Simone; Peeters, Andre; Tsivgoulis, Georgios; Roffe, Christine; Ahmed, Niaz; 2023; "sj-docx-1-wso-10.1177_17474930231180451 – Supplemental material for Reperfusion by endovascular thrombectomy and early cerebral edema in anterior circulation stroke: Results from the SITS-International Stroke Thrombectomy Registry [Dataset]"; Figshare; version 1; https://doi.org/10.25384/SAGE.23536902.v1 | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Ischaemic stroke | es_ES |
dc.subject | Cerebral edema | es_ES |
dc.subject | Reperfusion | es_ES |
dc.subject | Thrombolysis | es_ES |
dc.subject | Outcome | es_ES |
dc.subject | Intracerebral hemorrhage | es_ES |
dc.subject | Cerebral infarction | es_ES |
dc.title | Reperfusion by endovascular thrombectomy and early cerebral edema in anterior circulation stroke: Results from the SITS-International Stroke Thrombectomy Registry | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1177/17474930231180451 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1177/17474930231180451 | es_ES |
dc.identifier.e-issn | 1747-4949 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.contributor.funder | Karolinska Institutet Foundation | es_ES |
dc.contributor.funder | Stockholm County Council | es_ES |
dc.contributor.funder | Swedish Heart-Lung Foundation | es_ES |
dc.contributor.funder | Boehringer Ingelheim Fonds | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Ferrer International | es_ES |
dc.contributor.funder | EVER Pharma | es_ES |
dc.contributor.funder | Stryker | es_ES |
dc.contributor.funder | Covidien | es_ES |
dc.contributor.funder | Phenox | es_ES |
dc.contributor.funder | Karolinska Institute | es_ES |
dc.contributor.funder | Stiftelsen Tornspiran | es_ES |
dc.contributor.funder | Stiftelsen Sigurd and Elsa Goljes Minne | es_ES |
dc.contributor.funder | Swedish Stroke Association | es_ES |
dc.contributor.funder | Capios Research Foundation | es_ES |
dc.contributor.funder | Karolinska University Hospital | es_ES |
dc.contributor.funder | Junta de Andalucía | es_ES |
dc.contributor.funder | Biogen | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/100008894 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004047 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100001645 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002736 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100010819 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100007508 | es_ES |
dc.contributor.orcid | Escudero-Martínez, Irene [0000-0003-1838-0235] | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
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Reperfusion_IJS_2023_OA.pdf | 415,59 kB | Adobe PDF | Visualizar/Abrir |
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