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Título: | Higher plasma levels of thymosin-α1 are associated with a lower waning of humoral response after COVID-19 vaccination: an eight months follow-up study in a nursing home |
Autor: | Pozo-Balado, Maria del Mar del CSIC; Bulnes-Ramos, Ángel CSIC; Olivas-Martínez, Israel CSIC; Garrido-Rodríguez, Vanesa CSIC; Lozano, Carmen; Álvarez-Ríos, Ana Isabel CSIC ORCID; Sánchez-Sánchez, Berta; Sánchez-Bejarano, Encarnación; Maldonado-Calzado, Isabel; Martín-Lara, José Manuel; Santamaría, Juan Antonio; Bernal, Rafael; González-Escribano, María Francisca CSIC ORCID; Leal, Manuel CSIC; Pacheco, Yolanda M. CSIC ORCID | Palabras clave: | BNT162b2 vaccine Magnitude and persistence of humoral response Antibody waning Nursing home Thymic-function Sj/β-TRECs ratio RTL Thymosin-α1 Immunesenescence Inflammaging |
Fecha de publicación: | 6-mar-2023 | Editor: | BioMed Central Springer Nature |
Citación: | Immunity & Ageing 20: 9 (2023) | Resumen: | [Background] Older people achieve lower levels of antibody titers than younger populations after Covid-19 vaccination and show a marked waning humoral immunity over time, likely due to the senescence of the immune system. Nevertheless, age-related predictive factors of the waning humoral immune response to the vaccine have been scarcely explored. In a cohort of residents and healthcare workers from a nursing home that had received two doses of the BNT162b2 vaccine, we measured specific anti-S antibodies one (T1), four (T4), and eight (T8) months after receiving the second dose. Thymic-related functional markers, including thymic output, relative telomere length, and plasma thymosin-α1 levels, as well as immune cellular subsets, and biochemical and inflammatory biomarkers, were determined at T1, and tested for their associations with the magnitude of the vaccine response (T1) and the durability of such response both, at the short- (T1-T4) and the long-term (T1-T8). We aimed to identify age-related factors potentially associated with the magnitude and persistence of specific anti-S immunoglobulin G (IgG)-antibodies after COVID-19 vaccination in older people. [Results] Participants (100% men, n = 98), were subdivided into three groups: young (< 50 years-old), middle-age (50–65 years-old), and older (≥65 years-old). Older participants achieved lower antibody titers at T1 and experienced higher decreases in both the short- and long-term. In the entire cohort, while the magnitude of the initial response was mainly associated with the levels of homocysteine [β (95% CI); − 0.155 (− 0.241 to − 0.068); p = 0.001], the durability of such response at both, the short-term and the long-term were predicted by the levels of thymosin-α1 [− 0.168 (− 0.305 to − 0.031); p = 0.017, and − 0.123 (− 0.212 to − 0.034); p = 0.008, respectively]. [Conclusions] Higher plasma levels of thymosin-α1 were associated with a lower waning of anti-S IgG antibodies along the time. Our results suggest that plasma levels of thymosin-α1 could be used as a biomarker for predicting the durability of the responses after COVID-19 vaccination, possibly allowing to personalize the administration of vaccine boosters. |
Descripción: | © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | Versión del editor: | https://doi.org/10.1186/s12979-023-00334-y | URI: | http://hdl.handle.net/10261/350673 | DOI: | 10.1186/s12979-023-00334-y | ISSN: | 1742-4933 |
Aparece en las colecciones: | (IBIS) Artículos (PTI Salud Global) Colección Especial COVID-19 |
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Higher-plasma_IA_2023_OA.pdf | 1,14 MB | Adobe PDF | Visualizar/Abrir |
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