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Título: | Clinico-Pathological Features, Outcomes and Impacts of COVID-19 Pandemic on Patients with Early-Onset Colorectal Cancer: A Single-Institution Experience |
Autor: | Martínez-Pérez, Daniel; Viñal, David; Peña-Lopez, Jesús; Jiménez-Bou, Diego; Ruiz-Gutiérrez, Iciar; Martínez-Recio, S.; Alameda-Guijarro, María; Rueda-Lara, A.; Martin-Montalvo, G.; Ghanem, Ismael; Custodio, Ana Belén; Trilla-Fuertes, Lucía; Gámez, Ángelo CSIC ORCID; Barbáchano, Antonio CSIC ORCID; Rodríguez-Cobos, Javier; Bustamante-Madrid, Pilar CSIC ORCID; Fernández-Barral, Asunción CSIC ORCID; Burgos, Aurora; Prieto-Nieto, María Isabel; Pastrián, L. G.; González-Sancho, José Manuel CSIC ORCID; Muñoz Terol, Alberto CSIC ORCID; Feliu, Jaime; Rodríguez-Salas, Nuria | Palabras clave: | Early-onset colorectal cancer COVID-19 pandemic Prognosis |
Fecha de publicación: | 24-ago-2023 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Cancers 15(17): 4242 (2023) | Resumen: | [Background]: The rising incidence of colorectal cancer (CRC) among young patients is alarming. We aim to characterize the clinico-pathological features and outcomes of patients with early-onset CRC (EOCRC), as well as the impacts of COVID-19 pandemic. [Methods]: We included all patients with pathologically confirmed diagnoses of CRC at Hospital Universitario La Paz from October 2016 to December 2021. The EOCRC cut-off age was 50 years old. [Results]: A total of 1475 patients diagnosed with CRC were included, eighty (5.4%) of whom had EOCRC. Significant differences were found between EOCRC and later-onset patients regarding T, N stage and metastatic presentation at diagnosis; perineural invasion; tumor budding; high-grade tumors; and signet ring cell histology, with all issues having higher prevalence in the early-onset group. More EOCRC patients had the RAS/ BRAF wild type. Chemotherapy was administered more frequently to patients with EOCRC. In the metastatic setting, the EOCRC group presented a significantly longer median OS. Regarding the COVID-19 pandemic, more patients with COVID-19 were diagnosed with metastatic disease (61%) in the year after the lockdown (14 March 2020) than in the pre-pandemic EOCRC group (29%). [Conclusions]: EOCRC is diagnosed at a more advanced stage and with worse survival features in localized patients. More patients with EOCRC were diagnosed with metastatic disease in the year after the COVID-19 pandemic lockdown. The long-term consequences of COVID-19 are yet to be determined. |
Versión del editor: | https://doi.org/10.3390/cancers15174242 | URI: | http://hdl.handle.net/10261/349411 | DOI: | 10.3390/cancers15174242 | E-ISSN: | 2072-6694 |
Aparece en las colecciones: | (IIBM) Artículos (PTI Salud Global) Colección Especial COVID-19 |
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Clinico-Pathological-Features_Martínez_Art_2023.pdf | 1,97 MB | Adobe PDF | Visualizar/Abrir |
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