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http://hdl.handle.net/10261/348709
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Kelly, Louise | es_ES |
dc.contributor.author | Sharp, Matthew Macgregor | es_ES |
dc.contributor.author | Thomas, Isabelle | es_ES |
dc.contributor.author | Brown, Christopher | es_ES |
dc.contributor.author | Schrag, Matthew | es_ES |
dc.contributor.author | Antunes, Lissa Ventura | es_ES |
dc.contributor.author | Solopova, Elena | es_ES |
dc.contributor.author | Martínez-González, José | es_ES |
dc.contributor.author | Rodríguez-Sinovas, Cristina | es_ES |
dc.contributor.author | Carare, Roxana O. | es_ES |
dc.date.accessioned | 2024-02-28T16:29:36Z | - |
dc.date.available | 2024-02-28T16:29:36Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Cerebral Circulation - Cognition and Behavior 5: 100171 (2023) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/348709 | - |
dc.description.abstract | Alzheimer's disease is the commonest form of dementia. It is likely that a lack of clearance of amyloid beta (Aβ) results in its accumulation in the parenchyma as Aβ oligomers and insoluble plaques, and within the walls of blood vessels as cerebral amyloid angiopathy (CAA). The drainage of Aβ along the basement membranes of blood vessels as intramural periarterial drainage (IPAD), could be improved if the driving force behind IPAD could be augmented, therefore reducing Aβ accumulation. There are alterations in the composition of the vascular basement membrane in Alzheimer's disease. Lysyl oxidase (LOX) is an enzyme involved in the remodelling of the extracellular matrix and its expression and function is altered in various disease states. The expression of LOX is increased in Alzheimer's disease, but it is unclear whether this is a contributory factor in the impairment of IPAD in Alzheimer's disease. The pharmacological inhibition of LOX may be a strategy to improve IPAD and reduce the accumulation of Aβ in the parenchyma and within the walls of blood vessels. | es_ES |
dc.description.sponsorship | This work was supported by the Instituto de Salud Carlos III (ISCIII) (PI21/01048), the European Regional Development Fund (ERDF-FEDER, a way to build Europe), Ministerio de Ciencia e Innovación (PID2021-122509OB-I00) and The Royal Society (IESR2181107). | es_ES |
dc.format | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-122509OB-I00/ES/DESCIFRANDO EL PAPEL DE NOR-1 EN LA PROGRESION DEL ANEURISMA DE AORTA ABDOMINAL, LA ARRITMOGENESIS CARDIACA, Y LA FUNCION Y EL REMODELADO CARDIACO TRAS INFARTO DE MIOCARDIO/ | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.relation.isbasedon | The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1016/j.cccb.2023.100171 | - |
dc.rights | openAccess | es_ES |
dc.subject | Alzheimer's disease | es_ES |
dc.subject | Amyloid beta | es_ES |
dc.subject | Basement membrane | es_ES |
dc.subject | Cerebral amyloid angiopathy | es_ES |
dc.subject | Dementia | es_ES |
dc.subject | Lysyl oxidase | es_ES |
dc.title | Targeting lysyl-oxidase (LOX) may facilitate intramural periarterial drainage for the treatment of Alzheimer's disease | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.cccb.2023.100171 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.cccb.2023.100171 | es_ES |
dc.identifier.e-issn | 2666-2450 | - |
dc.rights.license | https://creativecommons.org/licenses/by-nc-nd/4.0/ | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación (España) | es_ES |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | es_ES |
dc.contributor.funder | Royal Society (UK) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000288 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.contributor.orcid | Kelly, Louise [0000-0002-5119-519X] | es_ES |
dc.identifier.pmid | 37457664 | - |
dc.identifier.scopus | 2-s2.0-85164150912 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85164150912 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | artículo | - |
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