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Título: | Fluvoxamine preferentially increases extracellular 5-hydroxytryptamine in the raphe nuclei: an in vivo microdialysis study |
Otros títulos: | Fluvoxamine increases preferentially extracellular 5-HT in the raphe nuclei of the awake rat. An in vivo microdialysis study | Autor: | Bel, Nuria; Artigas, Francesc CSIC ORCID | Palabras clave: | 5-hydroxytryptamine uptake Fluvoxamine Antidepressants Raphe nuclei Frontal cortex Microdialysis (in vivo) |
Fecha de publicación: | 8-dic-1992 | Editor: | Elsevier | Citación: | European Journal of Pharmacology 229 (1) :101-103 (1992) | Resumen: | The effects of systemic administration of fluvoxamine on extracellular serotonin (5-hydroxytryptamine, 5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in the frontal cortex and raphe nuclei of freely moving rats were examined. Fluvoxamine significantly increased extracellular 5-HT concentrations in both regions at the two doses used (1 and 10 mg/kg i.p.). However, the increase in the raphe nuclei was several-fold that in the frontal cortex. Dialysate 5-HIAA concentrations decreased after treatment with fluvoxamine. These results confirm that 5-HT uptake inhibitors preferentially increase extracellular concentrations of 5-HT in the vicinity of cell bodies and dendrites of serotonergic neurones. | Versión del editor: | http://dx.doi.org/10.1016/0014-2999(92)90292-C | URI: | http://hdl.handle.net/10261/34798 | DOI: | 10.1016/0014-2999(92)90292-C | ISSN: | 0014-2999 | E-ISSN: | 1879-0712 |
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