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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Arias, Clemente F. | es_ES |
dc.contributor.author | Valente-Leal, Nuno | es_ES |
dc.contributor.author | Bertocchini, Federica | es_ES |
dc.contributor.author | Marques, Sofia | es_ES |
dc.contributor.author | Acosta, Francisco Javier | es_ES |
dc.contributor.author | Fernandez-Arias, Cristina | es_ES |
dc.date.accessioned | 2024-02-15T12:41:49Z | - |
dc.date.available | 2024-02-15T12:41:49Z | - |
dc.date.issued | 2024-01-08 | - |
dc.identifier.citation | Communications Biology 7:58 (2024) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/347258 | - |
dc.description | 12 p.-7 fig. | es_ES |
dc.description.abstract | The regulation of red blood cell (RBC) homeostasis is widely assumed to rely on the control of cell production by erythropoietin (EPO) and the destruction of cells at a fixed, species-specific age. In this work, we show that such a regulatory mechanism would be a poor homeostatic solution to satisfy the changing needs of the body. Effective homeostatic control would require RBC lifespan to be variable and tightly regulated. We suggest that EPO may control RBC lifespan by determining CD47 expression in newly formed RBCs and SIRP-α expression in sinusoidal macrophages. EPO could also regulate the initiation and intensity of anti-RBC autoimmune responses that curtail RBC lifespan in some circumstances. These mechanisms would continuously modulate the rate of RBC destruction depending on oxygen availability. The control of RBC lifespan by EPO and autoimmunity emerges as a key mechanism in the homeostasis of RBCs. | es_ES |
dc.description.sponsorship | F.B. and C.F.A. are grateful to the Roechling Foundation for its support. Cr.F.A. and N.V.-L. were partially supported by the FCT grant no. EXPL/BIA-BIO-0644/2021. Cr.F.A. was partially supported by the MINECO grant PID2022-138187OB-I00. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer Nature | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-138187OB-I00/ES/DESENTRAÑANDO LAS IMPLICACIONES DEL DESEQUILIBRIO DE LA VIDA MEDIA DE LOS GLOBULOS ROJOS Y LA AUTOINMUNIDAD HOMEOSTATICA EN EL DESARROLLO DE ANEMIA EN MALARIA/ | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.title | A new role for erythropoietin in the homeostasis of red blood cells | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1038/s42003-023-05758-2 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1038/s42003-023-05758-2 | es_ES |
dc.identifier.e-issn | 2399-3642 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.contributor.funder | Röchling Foundation | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | Fundação para a Ciência e a Tecnologia (Portugal) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100001871 | es_ES |
dc.contributor.orcid | Arias, Clemente F. [0000-0003-4298-8910] | es_ES |
dc.contributor.orcid | Bertocchini, Federica [0000-0001-7241-0648] | es_ES |
dc.contributor.orcid | Fernandez-Arias, Cristina [0000-0002-3883-8795] | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
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Communications Biology_Arias_2024.pdf | Artículo principal | 1,16 MB | Adobe PDF | Visualizar/Abrir |
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