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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Álvarez, Enrique | es_ES |
dc.contributor.author | Falqui, Michela | es_ES |
dc.contributor.author | Sin, Laura | es_ES |
dc.contributor.author | McGrail, Joseph Patrick | es_ES |
dc.contributor.author | Perdiguero, Beatriz | es_ES |
dc.contributor.author | Coloma, Rocío | es_ES |
dc.contributor.author | Marcos-Villar, Laura | es_ES |
dc.contributor.author | Tárrega, Céline | es_ES |
dc.contributor.author | Esteban, Mariano | es_ES |
dc.contributor.author | Gómez, Carmen E. | es_ES |
dc.contributor.author | Guerra, Susana | es_ES |
dc.date.accessioned | 2024-02-04T11:21:13Z | - |
dc.date.available | 2024-02-04T11:21:13Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.citation | Vaccines 12(2): 153 (2024) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/345235 | - |
dc.description.abstract | The Interferon Stimulated Gene 15 (ISG15), a unique Ubiquitin-like (Ubl) modifier exclusive to vertebrates, plays a crucial role in the immune system. Primarily induced by interferon (IFN) type I, ISG15 functions through diverse mechanisms: (i) covalent protein modification (ISGylation); (ii) non-covalent intracellular action; and (iii) exerting extracellular cytokine activity. These various roles highlight its versatility in influencing numerous cellular pathways, encompassing DNA damage response, autophagy, antiviral response, and cancer-related processes, among others. The well-established antiviral effects of ISGylation contrast with its intriguing dual role in cancer, exhibiting both suppressive and promoting effects depending on the tumour type. The multifaceted functions of ISG15 extend beyond intracellular processes to extracellular cytokine signalling, influencing immune response, chemotaxis, and anti-tumour effects. Moreover, ISG15 emerges as a promising adjuvant in vaccine development, enhancing immune responses against viral antigens and demonstrating efficacy in cancer models. As a therapeutic target in cancer treatment, ISG15 exhibits a double-edged nature, promoting or suppressing oncogenesis depending on the tumour context. This review aims to contribute to future studies exploring the role of ISG15 in immune modulation and cancer therapy, potentially paving the way for the development of novel therapeutic interventions, vaccine development, and precision medicine. | es_ES |
dc.description.sponsorship | This research was supported by Spanish Ministry of Science and Innovation (MCIN)/Spanish State Research Agency, state secretary of R + D and FEDER/FSE grants: SAF2017-88089-R and PDC2021-121307-I00 to S.G. and M.E., PID2020-117425RB-C21 to S.G. and PID2020-117425RB-C22 to C.E.G. | es_ES |
dc.format | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-88089-R/ES/VACUNAS FRENTE A ENFERMEDADES HUMANAS PREVALENTES Y SU OPTIMIZACION: PAPEL DE ISG15/ | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PDC2021-121307-I00/ES/IMPACTO DEL VECTOR MVA-ISG15 EN LA INFECION POR SARS-COV-2%2FCOVID-19/ | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-117425RB-C21/ES/MODULACION DE LA RESPUESTA IMNUNE INNATA POR ISG15 Y SU IMPACTO EN LA RESPUESTA INMUNE ADAPTATIVA / | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-117425RB-C22/ES/NUEVAS PROTEINAS MULTIEPITOPICAS POLIVALENTES DIRIGIDAS A ACTIVAR CELULAS B Y T COMO CANDIDATOS VACUNALES FRENTE A VIH Y SARS-COV-2/ | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | IFN | es_ES |
dc.subject | ISG15 | es_ES |
dc.subject | ISGylation | es_ES |
dc.subject | Vaccines | es_ES |
dc.subject | Inflammation | es_ES |
dc.subject | Immunity | es_ES |
dc.subject | Adjuvant | es_ES |
dc.subject | Cytokines | es_ES |
dc.title | Unveiling the Multifaceted Roles of ISG15: From Immunomodulation to Therapeutic Frontiers | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.3390/vaccines12020153 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/vaccines12020153 | es_ES |
dc.identifier.e-issn | 2076-393X | - |
dc.date.updated | 2024-02-04T11:21:13Z | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación (España) | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.relation.csic | Sí | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | artículo | - |
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Unveiling the Multifaceted_Álvarez.pdf | 2,21 MB | Adobe PDF | Visualizar/Abrir |
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