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| Título: | Therapeutic treatment for t-cell acute lymphoblastic leukemias using a monoclonal antibody against the pre-T cell receptor |
Autor: | Toribio, María Luisa CSIC ORCID; Alarcón, Balbino CSIC ORCID; Alcaín, Juan CSIC ORCID; Bayón-Calderón, Fátima; Fuentes, Patricia; García-Peydró, Marina CSIC ORCID; González-García, Sara CSIC ORCID; Murcia-Ceballos, Alba | Fecha de publicación: | 18-may-2023 | Citación: | US2023151096 A1 | Resumen: | The present invention relates to the treatment of T-cell acute lymphoblastic leukemia (T-ALLs) by means of immunotherapy with a monoclonal antibody which recognizes the pre-TCR receptor which, due to its presence in all phases of T-ALL pre-TCR+ development, can also be used as a leukemia-initiating cell (LIC) biomarker and as a therapeutic target useful for monitoring minimal residual disease and identifying compounds inhibiting the disease. | URI: | http://hdl.handle.net/10261/342471 |
| Aparece en las colecciones: | (CBM) Patentes |
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| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| US2023151096A1.pdf | 7,59 MB | Adobe PDF |  Visualizar/Abrir |
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