Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/342321
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | The formin INF2 regulates basolateral-to-apical transcytosis and lumen formation in association with Cdc42 and MAL2 |
Autor: | Madrid, Ricardo CSIC; Aranda, Juan Francisco CSIC ORCID; Rodríguez-Fraticelli, Alejo E. CSIC; Ventimiglia, Leandro CSIC ORCID; Andrés-Delgado, Laura CSIC ORCID; Shehata, Mona; Fanayan, Susan; Shahheydari, Hamideh; Gómez, Sergio; Jiménez, Alberto CSIC ORCID CVN; Martín-Belmonte, Fernando CSIC ORCID; Byrne, Jennifer A.; Alonso, Miguel A. CSIC ORCID | Fecha de publicación: | 18-may-2010 | Editor: | Cell Press Elsevier |
Citación: | Developmental Cell 18(5): 814-827 (2010) | Resumen: | Transcytosis is a widespread pathway for apical targeting in epithelial cells. MAL2, an essential protein of the machinery for apical transcytosis, functions by shuttling in vesicular carriers between the apical zone and the cell periphery. We have identified INF2, an atypical formin with actin polymerization and depolymerization activities, which is a binding partner of MAL2. MAL2-positive vesicular carriers associate with short actin filaments during transcytosis in a process requiring INF2. INF2 binds Cdc42 in a GTP-loaded-dependent manner. Cdc42 and INF2 regulate MAL2 dynamics and are necessary for apical transcytosis and the formation of lateral lumens in hepatoma HepG2 cells. INF2 and MAL2 are also essential for the formation of the central lumen in organotypic cultures of epithelial MDCK cells. Our results reveal a functional mechanism whereby Cdc42, INF2, and MAL2 are sequentially ordered in a pathway dedicated to the regulation of transcytosis and lumen formation. © 2010 Elsevier Inc. | Versión del editor: | http://dx.doi.org/10.1016/j.devcel.2010.04.001 | URI: | http://hdl.handle.net/10261/342321 | DOI: | 10.1016/j.devcel.2010.04.001 | Identificadores: | doi: 10.1016/j.devcel.2010.04.001 issn: 1534-5807 e-issn: 1878-1551 |
Aparece en las colecciones: | (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
DevelomentalCell.pdf | 1,96 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
11
checked on 27-abr-2024
Download(s)
8
checked on 27-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.