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Título: | Anticoronavirus Evaluation of Antimicrobial Diterpenoids: Application of New Ferruginol Analogues |
Autor: | Varbanov, Mihayl; Philippot, Stephanie; González-Cardenete, Miguel A. CSIC ORCID | Fecha de publicación: | 9-jun-2023 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Viruses 15(6): 1342 (2023) | Resumen: | The abietane diterpene (+)-ferruginol (1), like other natural and semisynthetic abietanes, is distinguished for its interesting pharmacological properties such as antimicrobial activity, including antiviral. In this study, selected C18-functionalized semisynthetic abietanes prepared from the commercially available (+)-dehydroabietylamine or methyl dehydroabietate were tested in vitro against human coronavirus 229E (HCoV-229E). As a result, a new ferruginol analogue caused a relevant reduction in virus titer as well as the inhibition of a cytopathic effect. A toxicity prediction based on in silico analysis was also performed as well as an estimation of bioavailability. This work demonstrates the antimicrobial and specifically antiviral activity of two tested compounds, making these molecules interesting for the development of new antivirals. | Versión del editor: | http://dx.doi.org/10.3390/v15061342 | URI: | http://hdl.handle.net/10261/340423 | DOI: | 10.3390/v15061342 | Identificadores: | doi: 10.3390/v15061342 issn: 1999-4915 |
Aparece en las colecciones: | (ITQ) Artículos (PTI Salud Global) Colección Especial COVID-19 |
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