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Título: | 14-3-3 regulates the G2/M transition in the basidiomycete Ustilago maydis |
Autor: | Mielnichuk, Natalia CSIC; Pérez-Martín, José CSIC ORCID | Palabras clave: | Cell cycle 14-3-3 proteins Ustilago maydis Phytopathogenic fungi |
Fecha de publicación: | ago-2008 | Editor: | Elsevier | Citación: | Fungal Genetics and Biology 45(8): 1206-1215 (2008) | Resumen: | 14-3-3 proteins are a family of highly conserved polypeptides that function as small adaptors that facilitate a diverse array of cellular processes by binding phosphorylated target proteins. One of these processes is the regulation of the cell cycle. Here we characterized the role of Bmh1, a 14-3-3 protein, in the cell cycle regulation of the fungus Ustilago maydis. We found that this protein is essential in U. maydis and that it has roles during the G2/M transition in this organism. The function of 14-3-3 in U. maydis seems to mirror the proposed role for this protein during Schizosaccharomyces pombe cell cycle regulation. We provided evidence that in U. maydis 14-3-3 protein binds to the mitotic regulator Cdc25. Comparison of the roles of 14-3-3 during cell cycle regulation in other fungal system let us to discuss the connections between morphogenesis, cell cycle regulation and the evolutionary role of 14-3-3 proteins in fungi. | Versión del editor: | https://doi.org/10.1016/j.fgb.2008.05.010 | URI: | http://hdl.handle.net/10261/339000 | ISSN: | 1087-1845 |
Aparece en las colecciones: | (CNB) Artículos |
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