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http://hdl.handle.net/10261/337762
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dc.contributor.author | Sancho‐Albero, María | es_ES |
dc.contributor.author | Ayaz, Nazeeha | es_ES |
dc.contributor.author | Sebastián, Víctor | es_ES |
dc.contributor.author | Chirizzi, Cristina | es_ES |
dc.contributor.author | Encinas-Giménez, Miguel | es_ES |
dc.contributor.author | Neri, Giulia | es_ES |
dc.contributor.author | Chaabane, Linda | es_ES |
dc.contributor.author | Luján, Lluís | es_ES |
dc.contributor.author | Martín-Duque, Pilar | es_ES |
dc.contributor.author | Metrangolo, Pierangelo | es_ES |
dc.contributor.author | Santamaría, Jesús | es_ES |
dc.contributor.author | Baldelli Bombelli, Francesca | es_ES |
dc.date.accessioned | 2023-10-25T12:24:22Z | - |
dc.date.available | 2023-10-25T12:24:22Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | ACS Applied Materials and Interfaces 15(7): 8974-8985 (2023) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/337762 | - |
dc.description.abstract | Extracellular vesicles (EVs) play a crucial role in cell-to-cell communication and have great potential as efficient delivery vectors. However, a better understanding of EV in vivo behavior is hampered by the limitations of current imaging tools. In addition, chemical labels present the risk of altering the EV membrane features and, thus, in vivo behavior. 19F-MRI is a safe bioimaging technique providing selective images of exogenous probes. Here, we present the first example of fluorinated EVs containing PERFECTA, a branched molecule with 36 magnetically equivalent 19F atoms. A PERFECTA emulsion is given to the cells, and PERFECTA-containing EVs are naturally produced. PERFECTA-EVs maintain the physicochemical features, morphology, and biological fingerprint as native EVs but exhibit an intense 19F-NMR signal and excellent 19F relaxation times. In vivo 19F-MRI and tumor-targeting capabilities of stem cell-derived PERFECTA-EVs are also proved. We propose PERFECTA-EVs as promising biohybrids for imaging biodistribution and delivery of EVs throughout the body. | es_ES |
dc.description.sponsorship | M.S.-A. thanks the Spanish Government for the FPU PhD research fellowship (reference 15/03419) and the AIRC-Foundation for cancer research for a Postdoctoral fellowship in Italy. P.M.-D. also thanks the Instituto de Salud Carlos III (PI19/01007). The authors gratefully acknowledge financial support from the ERC Advance Grant CADENCE (grant no-ERC-2016-ADG-762684). V.S. acknowledges the financial support from Fundación Ramón Areces (XX Concurso nacional-Ciencias de la Vida y de la Materia) and Beca Leonardo a Investigadores y Creadores Culturales 2021 de la Fundación BBVA. V.S. also acknowledges the ICTS ELECMI (LMA-UNIZAR). N.A., F.B.B., and P.M. acknowledge financial support from Regione Lombardia (NEWMED project, ID: 1175999, POR FESR 2014 2020). F.B.B. and P.M. are also thankful for the projects Hydrogex funded by Cariplo Foundation (grant no. 2018-1720) and NiFTy funded by MUR (PRIN2017, no. 2017MYBTXC). The authors would also like to thank Prof. Jesús Ruiz-Cabello and Dr. Daniel Padro from CICbioMAGUNE for the 19F-MRI analysis and Scientific Services of the Aragon Institute of Health Sciences, specifically to the Microscopy, Pathology and Animal Facilities Services and their specialists. Dr Marina Cretich from “Istituto di Scienze e Tecnologie Chimiche” (SCITEC-CNR) in Milan, Italy, is acknowledged for the use of NTA Instrument. CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008–2011 financed by the Instituto de Salud Carlos III with the assistance of the European Regional Development Fund. CIBER-BBN (initiative funded by the VI National R&D&i Plan 2008–2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund) and Nanbiosis ICTS are gratefully acknowledged. “CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008–2011 financed by the Instituto de Salud Carlos III with the assistance of the European Regional Development Fund”. | es_ES |
dc.format | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/742684 | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Bioimaging | es_ES |
dc.subject | PERFECTA | es_ES |
dc.subject | 19F-MRI | es_ES |
dc.subject | Extracellular vesicles | es_ES |
dc.subject | Fluorine | es_ES |
dc.title | Superfluorinated extracellular vesicles for in vivo imaging by 19F-MRI | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1021/acsami.2c20566 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1021/acsami.2c20566 | es_ES |
dc.identifier.e-issn | 1944-8252 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.contributor.funder | Association for International Cancer Research | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | European Research Council | es_ES |
dc.contributor.funder | Fundación Ramón Areces | es_ES |
dc.contributor.funder | Fundación BBVA | es_ES |
dc.contributor.funder | Regione Lombardia | es_ES |
dc.contributor.funder | Ministero dell'Istruzione, dell'Università e della Ricerca | es_ES |
dc.contributor.funder | Fondazione Cariplo | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100008054 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100007406 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003407 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000781 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100004435 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002803 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100009882 | es_ES |
dc.identifier.pmid | 36780137 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
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superfluorinated.pdf | 9,66 MB | Adobe PDF | Visualizar/Abrir |
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