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Título: | Cellular alterations in carbohydrate and lipid metabolism due to interactions with nanomaterials |
Autor: | Martín-Pardillos, Ana CSIC ORCID; Martín-Duque, Pilar | Palabras clave: | Nanoparticles Metabolism Lipid Carbohydrate Diabetes Obesity Cancer Inflammation Oxidative stress |
Fecha de publicación: | 2023 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Journal of Functional Biomaterials 14(5): 274 (2023) | Resumen: | Nanoparticles (NPs) have unique physicochemical properties that are useful for a broad range of biomedical and industrial applications; nevertheless, increasing concern exists about their biosafety. This review aims to focus on the implications of nanoparticles in cellular metabolism and their outcomes. In particular, some NPs have the ability to modify glucose and lipid metabolism, and this feature is especially interesting to treat diabetes and obesity and to target cancer cells. However, the lack of specificity to reach target cells and the toxicological evaluation of nontargeted cells can potentially induce detrimental side effects, closely related to inflammation and oxidative stress. Therefore, identifying the metabolic alterations caused by NPs, independent of their application, is highly needed. To our knowledge, this increase would lead to the improvement and safer use with a reduced toxicity, increasing the number of available NPs for diagnosis and treatment of human diseases. | Descripción: | This article belongs to the Special Issue Micro and Nanocarriers for Biomedicine. | Versión del editor: | https://doi.org/10.3390/jfb14050274 | URI: | http://hdl.handle.net/10261/337693 | DOI: | 10.3390/jfb14050274 | E-ISSN: | 2079-4983 |
Aparece en las colecciones: | (INMA) Artículos |
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cellularnano.pdf | 1,32 MB | Adobe PDF | Visualizar/Abrir |
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