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Título: | Efficient Tumor Eradication at Ultralow Drug Concentration via Externally Controlled and Boosted Metallic Iron Magnetoplasmonic Nanocapsules [Dataset] |
Autor: | Fluksman, Arnon; Lafuente, Aritz; Li, Zhi CSIC ORCID; Sort, Jordi CSIC ORCID; Lope-Piedrafita, Silvia; Esplandiú, María J. CSIC ORCID; Nogués, Josep CSIC ORCID; Roca, Alejandro G. CSIC ORCID; Benny, Ofra; Sepúlveda, Borja CSIC ORCID | Palabras clave: | Nanoparticles partially coated Infrared biological windows Best plasmonic nanoheaters >- glycolic acid 13 – 3000 Photothermal efficiency similar Light actuation ). Nanodome shape iron Loaded polylactic -< Combining magnetic concentration Amplified therapeutic approach Efficient photothermal actuation Ultralow drug concentrations Drug therapeutic action Plga encapsulated drug Efficient tumor eradication Photothermal actuation Drug concentration Ultralow nanoparticle Loaded nanocapsules Iron semishell Complete eradication Therapeutic window Therapeutic effects Therapeutic assays Wide variety Vivo </ Silica semishell Results highlight Microfluidic channels Locally enhance Locally boost Large quantity High amplification Fold lower Ferromagnetic vortex Ferromagnetic material Externally controlled Different diseases co </ Cancer nanotherapies 1 mg |
Fecha de publicación: | 5-dic-2022 | Editor: | Figshare | Citación: | Fluksman, Arnon; Lafuente, Aritz; Li, Zhi; Sort, Jordi; Lope-Piedrafita, Silvia; Esplandiú, María J.; Nogués, Josep; Roca, Alejandro G.; Benny, Ofra; Sepúlveda, Borja; 2022; Efficient Tumor Eradication at Ultralow Drug Concentration via Externally Controlled and Boosted Metallic Iron Magnetoplasmonic Nanocapsules [Dataset]; Figshare; https://doi.org/10.1021/acsnano.2c05733.s001 | Resumen: | With the aim to locally enhance the efficacy of cancer nanotherapies, here we present metal iron based magnetoplasmonic drug-loaded nanocapsules (MAPSULES), merging powerful external magnetic concentration in the tumor and efficient photothermal actuation to locally boost the drug therapeutic action at ultralow drug concentrations. The MAPSULES are composed of paclitaxel-loaded polylactic-co-glycolic acid (PLGA) nanoparticles partially coated by a nanodome shape iron/silica semishell. The iron semishell has been designed to present a ferromagnetic vortex for incorporating a large quantity of ferromagnetic material while maintaining high colloidal stability. The large iron semishell provides very strong magnetic manipulation via magnetophoretic forces, enabling over 10-fold higher trapping efficiency in microfluidic channels than typical superparamagnetic iron oxide nanoparticles. Moreover, the iron semishell exhibits highly damped plasmonic behavior, yielding intense broadband absorbance in the near-infrared biological windows and photothermal efficiency similar to the best plasmonic nanoheaters. The in vivo therapeutic assays in a mouse xenograft tumor model show a high amplification of the therapeutic effects by combining magnetic concentration and photothermal actuation in the tumor, leading to a complete eradication of the tumors at ultralow nanoparticle and drug concentration (equivalent to only 1 mg/kg PLGA nanoparticles containing 8 μg/kg of paclitaxel, i.e., 100–500-fold lower than the therapeutic window of the free and PLGA encapsulated drug and 13–3000-fold lower than current nanotherapies combining paclitaxel and light actuation). These results highlight the strength of this externally controlled and amplified therapeutic approach, which could be applied to locally boost a wide variety of drugs for different diseases. | Descripción: | 8 pages. -- Figure S1. MAPSULES structural and colloidal characterization and drug release. -- Figure S2. Magnetic trapping experimental conditions. -- Figure S3. MAPSULES degradation evolution. -- Figure S4. Theoretical analysis of the absorption and scattering cross-sections and parameters for the calculation of the photothermal efficiency. -- Figure S5. In vivo biodistribution analysis by mass spectrometry. -- Figure S6. In vivo analysis of the photothermal effects without injected MAPSULES. -- Figure S7. In vivo safety analysis. -- Figure S8. Tumor progression. | Versión del editor: | https://doi.org/10.1021/acsnano.2c05733.s001 | URI: | http://hdl.handle.net/10261/336720 | DOI: | 10.1021/acsnano.2c05733.s001 | Referencias: | Fluksman, Arnon; Lafuente, Aritz; Li, Zhi; Sort, Jordi; Lope-Piedrafita, Silvia; Esplandiú, María J.; Nogués, Josep; Roca, Alejandro G.; Benny, Ofra; Sepúlveda, Borja. Efficient Tumor Eradication at Ultralow Drug Concentration via Externally Controlled and Boosted Metallic Iron Magnetoplasmonic Nanocapsules. https://doi.org/10.1021/acsnano.2c05733. http://hdl.handle.net/10261/336309 |
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Efficient_Tumor_Supplementary_Info.pdf | 706,59 kB | Adobe PDF | Visualizar/Abrir | |
README.txt | 3,99 kB | Text | Visualizar/Abrir |
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