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| Título: | Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity [Dataset] |
Autor: | Kaserman, Joseph E.; Werder, Rhiannon B.; Wang, Feiya; Matte, Taylor; Higgins, Michelle I.; Dodge, Mark; Lindstrom-Vautrin, Jonathan; Bawa, Pushpinder; Hinds, Anne; Bullitt, Esther; Caballero, Ignacio S.; Shi, Xu; Gerszten, Robert E.; Brunetti-Pierri, Nicola; Liesa, Marc CSIC ORCID ; Villacorta-Martin, Carlos; Hollenberg, Anthony N.; Kotton, Darrell N.; Wilson, Andrew A. | Fecha de publicación: | 6-dic-2022 | Editor: | Cell Press | Citación: | Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity [Dataset]; 2022; Kaserman, Joseph E.; Werder, Rhiannon B.; Wang, Feiya; Matte, Taylor; Higgins, Michelle I.; Dodge, Mark; Lindstrom-Vautrin, Jonathan; Bawa, Pushpinder; Hinds, Anne; Bullitt, Esther; Caballero, Ignacio S.; Shi, Xu; Gerszten, Robert E.; Brunetti-Pierri, Nicola; Liesa, Marc; Villacorta-Martin, Carlos; Hollenberg, Anthony N.; Kotton, Darrell N.; Wilson, Andrew A.; Cell Press; http://dx.doi.org/10.1016/j.celrep.2022.111775 | Descripción: | Figure S1: Characterization of MZ and MM CRISPR/Cas9 generated iPSCs and iPSC derived hepatic cells, related to Figure 1. Figure S2: MZ and ZZ iHeps Demonstrate Metabolic and Mitochondrial Dysregulation, related to Figure 3 and Figure 4. Figure S3: Transcriptional Heterogeneity and Branch-Specific Activation of the UPR In MZ and ZZ iHeps related to Figure 3 and Figure 5. Table S1: Results for differential expression testing, GSEA Hallmark pathways, and GO terms related to mitochondria, ER and ER stress for PiZZ6 ZZ, MZ and MM iHep pairwise comparisons, related to Figure 2. "Table S4: Results of differential expression testing, GSEA analysis by original identity and Enrichr-generated enrichments from the top 50 differentially expressed genes for each Louvain cluster and cluster 0 vs 1 comparisons from scRNA seq for PiZZ1 ZZ, MZ, MM and PiZZ6 ZZ, related to Figure 5." Table S5: Results of Enrichr-generated enrichments from the top 50 differentially expressed genes for each Louvain cluster from scRNA seq for PiZZ100 ZZ and MM, related to Figure 5. | Versión del editor: | https://doi.org/10.1016/j.celrep.2022.111775 | URI: | http://hdl.handle.net/10261/331492 | DOI: | 10.1016/j.celrep.2022.111775 | Referencias: | http://hdl.handle.net/10261/295514 |
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| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| Supplemental information_Human.pdf | 14,61 MB | Adobe PDF |  Visualizar/Abrir | |
| Table S1_Human.xlsx | 3,3 MB | Microsoft Excel XML | Visualizar/Abrir | |
| Table S4_HUman.xlsx | 1,85 MB | Microsoft Excel XML | Visualizar/Abrir | |
| Table S5_Human.xlsx | 29,22 kB | Microsoft Excel XML | Visualizar/Abrir |
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