Visual summary of the HLT model

Grau-Expósito, Judith; Perea, David; Suppi, Marina; Massana, Nuria; Vergara, Ander; Soler, María José; Trinité, Benjamin; Blanco, Julià; García-Pérez, Javier; Alcamí, José; Serrano-Mollar, Anna; Rosado, Joel; Falcó, Vicenç; Genesca, Meritxell; Buzón, María José

Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/329679

COMPARTIR / EXPORTAR:

SHARE BASE	Comparte tu historia de Acceso Abierto
Visualizar otros formatos: MARC \| Dublin Core \| RDF \| ORE \| MODS \| METS \| DIDL \| DATACITE
Refman EndNote Bibtex RefWorks Excel CSV PDF DataCite Send via email

Título:	Visual summary of the HLT model
Autor:	Grau-Expósito, Judith; Perea, David; Suppi, Marina; Massana, Nuria; Vergara, Ander; Soler, María José; Trinité, Benjamin; Blanco, Julià; García-Pérez, Javier; Alcamí, José CSIC ORCID; Serrano-Mollar, Anna CSIC ORCID; Rosado, Joel; Falcó, Vicenç; Genesca, Meritxell; Buzón, María José
Palabras clave:	term cell culture structural cell populations preserves main immune susceptible cell targets local inflammatory responses Viral entry inhibitors viral entry factors primary human cells highly reproducible method div >< p alveolar type ii new compounds missed modulate ace2 expression viral targets inflammatory compounds Viral infection new therapeutics 2 entry different compounds without long vitro rapid platform rapid method proteins involved potential therapeutics physiological models pathogen interactions identify host hlt cells hlt ), direct use differentiation approaches conventional systems antiviral testing antiviral activity also show
Fecha de publicación:	13-ene-2022
Editor:	Figshare
Citación:	Grau-Expósito, Judith; Perea, David; Suppi, Marina; Massana, Nuria; Vergara, Ander; Soler, María José; Trinité, Benjamin; Blanco, Julià; García-Pérez, Javier; Alcamí, José; Serrano-Mollar, Anna; Rosado, Joel; Falcó, Vicenç; Genesca, Meritxell; Buzón, María José; 2022; Visual summary of the HLT model; Figshare; https://doi.org/10.1371/journal.ppat.1010171.s001
Resumen:	Ex vivo physiological systems for the study of SARS-CoV-2-host interactions are scarce. We establish a method using primary human lung tissue (HLT) cells for the rapid analysis of cell tropism and identification of therapeutics. Main findings: i) HLT cells preserve main cell subpopulations, including alveolar type-II cells, and expression of SARS-CoV-2 entry factors ACE2, CD147, TMPRSS2 and AXL. ii) HLT cells are readily susceptible to SARS-CoV-2 infection without the need of cell isolation or further cell differentiation. iii) Antiviral testing in HLT cells allows the rapid identification of new drug candidates against SARS-CoV-2 variants, missed by conventional systems. iv) Local inflammation is supported in HLT cells and offers the identification of relevant anti-inflammatory compounds for SARS-CoV-2 infection.
Versión del editor:	https://doi.org/10.1371/journal.ppat.1010171.s001
URI:	http://hdl.handle.net/10261/329679
DOI:	https://doi.org/10.20350/digitalCSIC/15368
ISSN:	10.1371/journal.ppat.1010171.s001
Referencias:	Grau-Expósito, Judith; Perea, David; Suppi, Marina; Massana, Nuria; Vergara, Ander; Soler, María José; Trinité, Benjamin; Blanco, Julià; García-Pérez, Javier; Alcamí, José; Serrano-Mollar, Anna; Rosado, Joel; Falcó, Vicenç; Genesca, Meritxell; Buzón, María José. Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells. https://doi.org/10.1371/journal.ppat.1010171. http://hdl.handle.net/10261/268646
Aparece en las colecciones:	(IIBB) Conjuntos de datos (PTI Salud Global) Colección Especial COVID-19