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dc.contributor.author | Riquelme, Raquel | - |
dc.contributor.author | Cediel, Rafael | - |
dc.contributor.author | Contreras, Julio | - |
dc.contributor.author | Rodriguez-de la Rosa, Lourdes | - |
dc.contributor.author | Murillo-Cuesta, Silvia | - |
dc.contributor.author | Hernández-Sánchez, Catalina | - |
dc.contributor.author | Zubeldia, José M. | - |
dc.contributor.author | Cerdán, Sebastián | - |
dc.contributor.author | Varela-Nieto, Isabel | - |
dc.date.accessioned | 2011-01-26T10:57:03Z | - |
dc.date.available | 2011-01-26T10:57:03Z | - |
dc.date.issued | 2010-07-13 | - |
dc.identifier.citation | Frontiers in Neuroanatomy 4: 27 (2010) | es_ES |
dc.identifier.issn | 1662-5129 | - |
dc.identifier.uri | http://hdl.handle.net/10261/31549 | - |
dc.description.abstract | Insulin-like growth factor-I (IGF-I) belongs to the family of insulin-related peptides that fulfils a key role during the late development of the nervous system. Human IGF1 mutations cause profound deafness, poor growth and mental retardation. Accordingly, Igf1(-/-) null mice are dwarfs that have low survival rates, cochlear alterations and severe sensorineural deafness. Presbycusis (age-related hearing loss) is a common disorder associated with aging that causes social and cognitive problems. Aging is also associated with a decrease in circulating IGF-I levels and this reduction has been related to cognitive and brain alterations, although there is no information as yet regarding the relationship between presbycusis and IGF-I biodisponibility. Here we present a longitudinal study of wild type Igf1(+/+) and null Igf1(-/-) mice from 2 to 12 months of age comparing the temporal progression of several parameters: hearing, brain morphology, cochlear cytoarchitecture, insulin-related factors and IGF gene expression and IGF-I serum levels. Complementary invasive and non-invasive techniques were used, including auditory brainstem-evoked response (ABR) recordings and in vivo MRI brain imaging. Igf1(-/-) null mice presented profound deafness at all the ages studied, without any obvious worsening of hearing parameters with aging. Igf1(+/+) wild type mice suffered significant age-related hearing loss, their auditory thresholds and peak I latencies augmenting as they aged, in parallel with a decrease in the circulating levels of IGF-I. Accordingly, there was an age-related spiral ganglion degeneration in wild type mice that was not evident in the Igf1 null mice. However, the Igf1(-/-) null mice in turn developed a prematurely aged stria vascularis reminiscent of the diabetic strial phenotype. Our data indicate that IGF-I is required for the correct development and maintenance of hearing, supporting the idea that IGF-I-based therapies could contribute to prevent or ameliorate age-related hearing loss. | es_ES |
dc.description.sponsorship | This work was partially supported by grants to IVN from DIGNA Biotech, the Ministerio de Ciencia e Innovacion (SAF2008-00470) and from the Fundacion Mutua Madrileña to IVN and JMZ. | - |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | es_ES |
dc.subject | Aging | es_ES |
dc.subject | Auditory brainstem responses | es_ES |
dc.subject | Deafness | es_ES |
dc.subject | Igf1-/- null mouse | es_ES |
dc.subject | Insuline-like factors | es_ES |
dc.subject | In vivo brain imaging | es_ES |
dc.subject | Presbycusis | es_ES |
dc.subject | Sensorineural deafness | es_ES |
dc.title | A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.3389/fnana.2010.00027 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.3389/fnana.2010.00027 | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.contributor.funder | Fundación Mutua Madrileña | - |
dc.contributor.funder | Digna Biotech | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100008061 | es_ES |
dc.identifier.pmid | 20661454 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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Frontiers in neuroanatomy 2010 vol4 art27 pp1.pdf | 2,98 MB | Adobe PDF | Visualizar/Abrir |
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